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The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore.
Brookes PS, Morse K, Ray D, Tompkins A, Young SM, Hilchey S, Salim S, Konopleva M, Andreeff M, Phipps R, Bernstein SH. Brookes PS, et al. Cancer Res. 2007 Feb 15;67(4):1793-802. doi: 10.1158/0008-5472.CAN-06-2678. Cancer Res. 2007. PMID: 17308122
NDUFS4: creation of a mouse model mimicking a Complex I disorder.
Ingraham CA, Burwell LS, Skalska J, Brookes PS, Howell RL, Sheu SS, Pinkert CA. Ingraham CA, et al. Among authors: brookes ps. Mitochondrion. 2009 Jun;9(3):204-10. doi: 10.1016/j.mito.2009.02.001. Epub 2009 Feb 11. Mitochondrion. 2009. PMID: 19460290 Free PMC article.
Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation.
Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI. Kotla S, et al. Among authors: brookes ps. Redox Biol. 2021 Nov;47:102132. doi: 10.1016/j.redox.2021.102132. Epub 2021 Sep 20. Redox Biol. 2021. PMID: 34619528 Free PMC article.
Ischemic preconditioning: the role of mitochondria and aging.
Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K. Wojtovich AP, et al. Among authors: brookes ps. Exp Gerontol. 2012 Jan;47(1):1-7. doi: 10.1016/j.exger.2011.11.001. Epub 2011 Nov 10. Exp Gerontol. 2012. PMID: 22100642 Free PMC article. Review.
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.
Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, Grose V, O'Dwyer KM, Liesveld JL, Brookes PS, Becker MW, Jordan CT. Lagadinou ED, et al. Among authors: brookes ps. Cell Stem Cell. 2013 Mar 7;12(3):329-41. doi: 10.1016/j.stem.2012.12.013. Epub 2013 Jan 17. Cell Stem Cell. 2013. PMID: 23333149 Free PMC article.
237 results