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Page 1
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.
Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J, Collins A, Romartínez-Alonso B, Tadross JA, Jia R, Gardner EJ, Kentistou K, Zhao Y, Day F, Mörseburg A, Rainbow K, Rimmington D, Mastantuoni M, Harrison J, Nus M, Guma'a K, Sherratt-Mayhew S, Jiang X, Smith KR, Paul DS, Jenkins B, Koulman A, Pietzner M, Langenberg C, Wareham N, Yeo GS, Chatterjee K, Schwabe J, Oakley F, Mann DA, Tontonoz P, Coll AP, Ong K, Perry JRB, O'Rahilly S. Lockhart SM, et al. Nat Metab. 2024 Oct;6(10):1922-1938. doi: 10.1038/s42255-024-01126-4. Epub 2024 Sep 25. Nat Metab. 2024. PMID: 39322746 Free PMC article.
Structural basis for the activation of PPARgamma by oxidized fatty acids.
Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW. Itoh T, et al. Among authors: schwabe jw. Nat Struct Mol Biol. 2008 Sep;15(9):924-31. doi: 10.1038/nsmb.1474. Nat Struct Mol Biol. 2008. PMID: 19172745 Free PMC article.
Negative regulation by nuclear receptors: a plethora of mechanisms.
Santos GM, Fairall L, Schwabe JW. Santos GM, et al. Among authors: schwabe jw. Trends Endocrinol Metab. 2011 Mar;22(3):87-93. doi: 10.1016/j.tem.2010.11.004. Epub 2010 Dec 31. Trends Endocrinol Metab. 2011. PMID: 21196123 Free PMC article. Review.
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW. Oberoi J, et al. Among authors: schwabe jw. Nat Struct Mol Biol. 2011 Feb;18(2):177-84. doi: 10.1038/nsmb.1983. Epub 2011 Jan 16. Nat Struct Mol Biol. 2011. PMID: 21240272 Free PMC article.
Nuclear hormone receptor co-repressors: structure and function.
Watson PJ, Fairall L, Schwabe JW. Watson PJ, et al. Among authors: schwabe jw. Mol Cell Endocrinol. 2012 Jan 30;348(2):440-9. doi: 10.1016/j.mce.2011.08.033. Epub 2011 Sep 8. Mol Cell Endocrinol. 2012. PMID: 21925568 Free PMC article. Review.
Class I HDACs share a common mechanism of regulation by inositol phosphates.
Millard CJ, Watson PJ, Celardo I, Gordiyenko Y, Cowley SM, Robinson CV, Fairall L, Schwabe JW. Millard CJ, et al. Among authors: schwabe jw. Mol Cell. 2013 Jul 11;51(1):57-67. doi: 10.1016/j.molcel.2013.05.020. Epub 2013 Jun 20. Mol Cell. 2013. PMID: 23791785 Free PMC article.
An evolving understanding of nuclear receptor coregulator proteins.
Millard CJ, Watson PJ, Fairall L, Schwabe JW. Millard CJ, et al. Among authors: schwabe jw. J Mol Endocrinol. 2013 Nov 7;51(3):T23-36. doi: 10.1530/JME-13-0227. Print 2013 Dec. J Mol Endocrinol. 2013. PMID: 24203923 Free PMC article. Review.
123 results