Jiang H - Search Results

1

Development and characterization of a pre-treatment procedure to eliminate human monoclonal antibody therapeutic drug and matrix interference in cell-based functional neutralizing antibody assays.

Xu W, Jiang H, Titsch C, Haulenbeek JR, Pillutla RC, Aubry AF, DeSilva BS, Arnold ME, Zeng J, Dodge RW. Xu W, et al. Among authors: jiang h. J Immunol Methods. 2015 Jan;416:94-104. doi: 10.1016/j.jim.2014.11.005. Epub 2014 Nov 8. J Immunol Methods. 2015. PMID: 25445325

2

Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

Jiang H, Xu W, Titsch CA, Furlong MT, Dodge R, Voronin K, Allentoff A, Zeng J, Aubry AF, DeSilva BS, Arnold ME. Jiang H, et al. Anal Chem. 2014 Mar 4;86(5):2673-80. doi: 10.1021/ac5001465. Epub 2014 Feb 17. Anal Chem. 2014. PMID: 24506335

3

Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.

Gu H, Wang J, Aubry AF, Jiang H, Zeng J, Easter J, Wang JS, Dockens R, Bifano M, Burrell R, Arnold ME. Gu H, et al. Among authors: jiang h. Anal Chem. 2012 Jun 5;84(11):4844-50. doi: 10.1021/ac300442v. Epub 2012 May 10. Anal Chem. 2012. PMID: 22540405

4

Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.

Jiang H, Zeng J, Li W, Bifano M, Gu H, Titsch C, Easter J, Burrell R, Kandoussi H, Aubry AF, Arnold ME. Jiang H, et al. Anal Chem. 2012 Nov 20;84(22):10031-7. doi: 10.1021/ac3024558. Epub 2012 Nov 6. Anal Chem. 2012. PMID: 23106420

5

A rugged and accurate liquid chromatography-tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma.

Yuan L, Jiang H, Ouyang Z, Xia YQ, Zeng J, Peng Q, Lange RW, Deng Y, Arnold ME, Aubry AF. Yuan L, et al. Among authors: jiang h. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Mar 15;921-922:81-6. doi: 10.1016/j.jchromb.2013.01.029. Epub 2013 Feb 4. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23435345

6

Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Jiang H, Zeng J, Titsch C, Voronin K, Akinsanya B, Luo L, Shen H, Desai DD, Allentoff A, Aubry AF, Desilva BS, Arnold ME. Jiang H, et al. Anal Chem. 2013 Oct 15;85(20):9859-67. doi: 10.1021/ac402420v. Epub 2013 Sep 26. Anal Chem. 2013. PMID: 24024648

7

Sensitivity-based analytical approaches to support human absolute bioavailability studies.

Xu XS, Jiang H, Christopher LJ, Shen JX, Zeng J, Arnold ME. Xu XS, et al. Among authors: jiang h. Bioanalysis. 2014 Feb;6(4):497-504. doi: 10.4155/bio.13.318. Bioanalysis. 2014. PMID: 24568352

8

An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies.

Furlong MT, Titsch C, Xu W, Jiang H, Jemal M, Zeng J. Furlong MT, et al. Among authors: jiang h. Bioanalysis. 2014;6(13):1747-58. doi: 10.4155/bio.14.64. Epub 2014 Mar 24. Bioanalysis. 2014. PMID: 24661028

9

Development and validation of an LC-MS/MS assay for the quantitation of a PEGylated anti-CD28 domain antibody in human serum: overcoming interference from antidrug antibodies and soluble target.

Gong C, Zeng J, Akinsanya B, Jiang H, Mora J, Chilewski S, Gambardella J, Allentoff A, Gleason C, Aubry AF, DeSilva BS, Arnold ME. Gong C, et al. Among authors: jiang h. Bioanalysis. 2014 Sep;6(18):2371-83. doi: 10.4155/bio.14.181. Bioanalysis. 2014. PMID: 25384590

10

Overcoming interference with the detection of a stable isotopically labeled microtracer in the evaluation of beclabuvir absolute bioavailability using a concomitant microtracer approach.

Jiang H, Titsch C, Zeng J, Jones B, Joyce P, Gandhi Y, Turley W, Burrell R, Aubry AF, Arnold ME. Jiang H, et al. J Pharm Biomed Anal. 2017 Sep 5;143:9-16. doi: 10.1016/j.jpba.2017.04.030. Epub 2017 May 17. J Pharm Biomed Anal. 2017. PMID: 28544885

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