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Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.
Han C, Chatterjee A, Noetzel MJ, Panarese JD, Smith E, Chase P, Hodder P, Niswender C, Conn PJ, Lindsley CW, Stauffer SR. Han C, et al. Among authors: niswender c. Bioorg Med Chem Lett. 2015 Jan 15;25(2):384-8. doi: 10.1016/j.bmcl.2014.11.011. Epub 2014 Nov 18. Bioorg Med Chem Lett. 2015. PMID: 25435150 Free PMC article.
mGluR7's lucky number.
Conn PJ, Niswender CM. Conn PJ, et al. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):251-2. doi: 10.1073/pnas.0510051103. Epub 2006 Jan 3. Proc Natl Acad Sci U S A. 2006. PMID: 16407154 Free PMC article. No abstract available.
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, Williams R, Lindsley CW, Conn PJ. Niswender CM, et al. Mol Pharmacol. 2008 Nov;74(5):1345-58. doi: 10.1124/mol.108.049551. Epub 2008 Jul 29. Mol Pharmacol. 2008. PMID: 18664603 Free PMC article.
272 results