Pierce GF - Search Results

1

A single chain variant of factor VIII Fc fusion protein retains normal in vivo efficacy but exhibits altered in vitro activity.

Buyue Y, Liu T, Kulman JD, Toby GG, Kamphaus GD, Patarroyo-White S, Lu Q, Reidy TJ, Mei B, Jiang H, Pierce GF, Sommer JM, Peters RT. Buyue Y, et al. Among authors: pierce gf. PLoS One. 2014 Nov 21;9(11):e113600. doi: 10.1371/journal.pone.0113600. eCollection 2014. PLoS One. 2014. PMID: 25415306 Free PMC article.

2

Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice.

Scallan CD, Jiang H, Liu T, Patarroyo-White S, Sommer JM, Zhou S, Couto LB, Pierce GF. Scallan CD, et al. Among authors: pierce gf. Blood. 2006 Mar 1;107(5):1810-7. doi: 10.1182/blood-2005-08-3229. Epub 2005 Oct 25. Blood. 2006. PMID: 16249376 Free article.

3

Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs.

Jiang H, Lillicrap D, Patarroyo-White S, Liu T, Qian X, Scallan CD, Powell S, Keller T, McMurray M, Labelle A, Nagy D, Vargas JA, Zhou S, Couto LB, Pierce GF. Jiang H, et al. Among authors: pierce gf. Blood. 2006 Jul 1;108(1):107-15. doi: 10.1182/blood-2005-12-5115. Epub 2006 Mar 7. Blood. 2006. PMID: 16522813 Free article.

4

Improved coagulation in bleeding disorders by Non-Anticoagulant Sulfated Polysaccharides (NASP).

Liu T, Scallan CD, Broze GJ Jr, Patarroyo-White S, Pierce GF, Johnson KW. Liu T, et al. Among authors: pierce gf. Thromb Haemost. 2006 Jan;95(1):68-76. Thromb Haemost. 2006. PMID: 16543964

5

Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B.

Jiang H, Pierce GF, Ozelo MC, de Paula EV, Vargas JA, Smith P, Sommer J, Luk A, Manno CS, High KA, Arruda VR. Jiang H, et al. Among authors: pierce gf. Mol Ther. 2006 Sep;14(3):452-5. doi: 10.1016/j.ymthe.2006.05.004. Epub 2006 Jul 5. Mol Ther. 2006. PMID: 16822719 Free article. Clinical Trial.

6

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy.

Jiang H, Couto LB, Patarroyo-White S, Liu T, Nagy D, Vargas JA, Zhou S, Scallan CD, Sommer J, Vijay S, Mingozzi F, High KA, Pierce GF. Jiang H, et al. Among authors: pierce gf. Blood. 2006 Nov 15;108(10):3321-8. doi: 10.1182/blood-2006-04-017913. Epub 2006 Jul 25. Blood. 2006. PMID: 16868252 Free PMC article.

7

The enhancing effects of the light chain on heavy chain secretion in split delivery of factor VIII gene.

Chen L, Zhu F, Li J, Lu H, Jiang H, Sarkar R, Arruda VR, Wang J, Zhao J, Pierce GF, Ding Q, Wang X, Wang H, Pipe SW, Liu XQ, Xiao X, Camire RM, Xiao W. Chen L, et al. Among authors: pierce gf. Mol Ther. 2007 Oct;15(10):1856-62. doi: 10.1038/sj.mt.6300268. Epub 2007 Jul 24. Mol Ther. 2007. PMID: 17653101 Free PMC article.

8

Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice.

Pan J, Liu T, Kim JY, Zhu D, Patel C, Cui ZH, Zhang X, Newgren JO, Reames A, Canivel D, Jesmok G, Pierce GF, Sommer JM, Jiang H. Pan J, et al. Among authors: pierce gf. Blood. 2009 Sep 24;114(13):2802-11. doi: 10.1182/blood-2009-03-212423. Epub 2009 Aug 4. Blood. 2009. PMID: 19654409 Free article.

9

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment.

Mei B, Pan C, Jiang H, Tjandra H, Strauss J, Chen Y, Liu T, Zhang X, Severs J, Newgren J, Chen J, Gu JM, Subramanyam B, Fournel MA, Pierce GF, Murphy JE. Mei B, et al. Among authors: pierce gf. Blood. 2010 Jul 15;116(2):270-9. doi: 10.1182/blood-2009-11-254755. Epub 2010 Mar 1. Blood. 2010. PMID: 20194895 Free article.

10

Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients.

Shapiro AD, Ragni MV, Valentino LA, Key NS, Josephson NC, Powell JS, Cheng G, Thompson AR, Goyal J, Tubridy KL, Peters RT, Dumont JA, Euwart D, Li L, Hallén B, Gozzi P, Bitonti AJ, Jiang H, Luk A, Pierce GF. Shapiro AD, et al. Among authors: pierce gf. Blood. 2012 Jan 19;119(3):666-72. doi: 10.1182/blood-2011-07-367003. Epub 2011 Nov 22. Blood. 2012. PMID: 22110246 Free PMC article. Clinical Trial.

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