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Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.
Hanessian S, Szychowski J, Adhikari SS, Vasquez G, Kandasamy P, Swayze EE, Migawa MT, Ranken R, François B, Wirmer-Bartoschek J, Kondo J, Westhof E. Hanessian S, et al. Among authors: migawa mt. J Med Chem. 2007 May 17;50(10):2352-69. doi: 10.1021/jm061200+. Epub 2007 Apr 26. J Med Chem. 2007. PMID: 17458946
Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria.
Hanessian S, Pachamuthu K, Szychowski J, Giguère A, Swayze EE, Migawa MT, François B, Kondo J, Westhof E. Hanessian S, et al. Among authors: migawa mt. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7097-101. doi: 10.1016/j.bmcl.2010.09.084. Epub 2010 Sep 19. Bioorg Med Chem Lett. 2010. PMID: 20970332
Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA.
Rajasekaran T, Freestone GC, Galindo-Murillo R, Lugato B, Rico L, Salinas JC, Gaus H, Migawa MT, Swayze EE, Cheatham TE 3rd, Hanessian S, Seth PP. Rajasekaran T, et al. Among authors: migawa mt. J Am Chem Soc. 2022 Feb 2;144(4):1941-1950. doi: 10.1021/jacs.1c12323. Epub 2022 Jan 18. J Am Chem Soc. 2022. PMID: 35041415 Free PMC article.
Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.
Prakash TP, Siwkowski A, Allerson CR, Migawa MT, Lee S, Gaus HJ, Black C, Seth PP, Swayze EE, Bhat B. Prakash TP, et al. Among authors: migawa mt. J Med Chem. 2010 Feb 25;53(4):1636-50. doi: 10.1021/jm9013295. J Med Chem. 2010. PMID: 20108935
43 results