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Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR).
Caohuy H, Yang Q, Eudy Y, Ha TA, Xu AE, Glover M, Frizzell RA, Jozwik C, Pollard HB. Caohuy H, et al. Among authors: jozwik c. J Biol Chem. 2014 Dec 26;289(52):35953-68. doi: 10.1074/jbc.M114.598649. Epub 2014 Nov 10. J Biol Chem. 2014. PMID: 25384981 Free PMC article.
Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells.
Srivastava M, Eidelman O, Zhang J, Paweletz C, Caohuy H, Yang Q, Jacobson KA, Heldman E, Huang W, Jozwik C, Pollard BS, Pollard HB. Srivastava M, et al. Among authors: jozwik c. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7693-8. doi: 10.1073/pnas.0402030101. Epub 2004 May 10. Proc Natl Acad Sci U S A. 2004. PMID: 15136726 Free PMC article.
Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor.
Yang Q, Huang W, Jozwik C, Lin Y, Glasman M, Caohuy H, Srivastava M, Esposito D, Gillette W, Hartley J, Pollard HB. Yang Q, et al. Among authors: jozwik c. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9631-6. doi: 10.1073/pnas.0504097102. Epub 2005 Jun 27. Proc Natl Acad Sci U S A. 2005. PMID: 15983368 Free PMC article.
De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cells.
Pollard HB, Eidelman O, Jozwik C, Huang W, Srivastava M, Ji XD, McGowan B, Norris CF, Todo T, Darling T, Mogayzel PJ, Zeitlin PL, Wright J, Guggino WB, Metcalf E, Driscoll WJ, Mueller G, Paweletz C, Jacobowitz DM. Pollard HB, et al. Among authors: jozwik c. Mol Cell Proteomics. 2006 Sep;5(9):1628-37. doi: 10.1074/mcp.M600091-MCP200. Epub 2006 Jul 7. Mol Cell Proteomics. 2006. PMID: 16829594 Free article.
In previous studies with cystic fibrosis (CF) IB3-1 lung epithelial cells in culture, we identified 194 unique high abundance proteins by conventional two-dimensional gel electrophoresis and mass spectrometry (Pollard, H. B., Ji, X.-D., Jozwik, C. J., and Jacobowitz …
In previous studies with cystic fibrosis (CF) IB3-1 lung epithelial cells in culture, we identified 194 unique high abundance proteins by co …
Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells.
Balakathiresan NS, Bhattacharyya S, Gutti U, Long RP, Jozwik C, Huang W, Srivastava M, Pollard HB, Biswas R. Balakathiresan NS, et al. Among authors: jozwik c. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L1012-8. doi: 10.1152/ajplung.90601.2008. Epub 2009 Apr 10. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19363120 Free PMC article.
Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.
Caohuy H, Jozwik C, Pollard HB. Caohuy H, et al. Among authors: jozwik c. J Biol Chem. 2009 Sep 11;284(37):25241-53. doi: 10.1074/jbc.M109.035345. Epub 2009 Jul 17. J Biol Chem. 2009. PMID: 19617352 Free PMC article.
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