Spiegel DA - Search Results

1

Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules.

Parker CG, Dahlgren MK, Tao RN, Li DT, Douglass EF Jr, Shoda T, Jawanda N, Spasov KA, Lee S, Zhou N, Domaoal RA, Sutton RE, Anderson KS, Jorgensen WL, Krystal M, Spiegel DA. Parker CG, et al. Among authors: spiegel da. Chem Sci. 2014 Jun 1;5(6):2311-2317. doi: 10.1039/C4SC00484A. Chem Sci. 2014. PMID: 25379167 Free PMC article.

2

An antibody-recruiting small molecule that targets HIV gp120.

Parker CG, Domaoal RA, Anderson KS, Spiegel DA. Parker CG, et al. Among authors: spiegel da. J Am Chem Soc. 2009 Nov 18;131(45):16392-4. doi: 10.1021/ja9057647. J Am Chem Soc. 2009. PMID: 19839582 Free PMC article.

3

Chemical control over immune recognition: a class of antibody-recruiting small molecules that target prostate cancer.

Murelli RP, Zhang AX, Michel J, Jorgensen WL, Spiegel DA. Murelli RP, et al. Among authors: spiegel da. J Am Chem Soc. 2009 Dec 2;131(47):17090-2. doi: 10.1021/ja906844e. J Am Chem Soc. 2009. PMID: 19888723 Free PMC article.

4

A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules.

Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A, Jorgensen WL, Lubkowski J, Spiegel DA. Zhang AX, et al. Among authors: spiegel da. J Am Chem Soc. 2010 Sep 15;132(36):12711-6. doi: 10.1021/ja104591m. J Am Chem Soc. 2010. PMID: 20726553 Free PMC article.

5

Reprogramming urokinase into an antibody-recruiting anticancer agent.

Jakobsche CE, McEnaney PJ, Zhang AX, Spiegel DA. Jakobsche CE, et al. Among authors: spiegel da. ACS Chem Biol. 2012 Feb 17;7(2):316-21. doi: 10.1021/cb200374e. Epub 2011 Nov 18. ACS Chem Biol. 2012. PMID: 22098560 Free PMC article.

6

Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease.

McEnaney PJ, Parker CG, Zhang AX, Spiegel DA. McEnaney PJ, et al. Among authors: spiegel da. ACS Chem Biol. 2012 Jul 20;7(7):1139-51. doi: 10.1021/cb300119g. Epub 2012 Jul 3. ACS Chem Biol. 2012. PMID: 22758917 Free PMC article. Review.

7

A comprehensive mathematical model for three-body binding equilibria.

Douglass EF Jr, Miller CJ, Sparer G, Shapiro H, Spiegel DA. Douglass EF Jr, et al. Among authors: spiegel da. J Am Chem Soc. 2013 Apr 24;135(16):6092-9. doi: 10.1021/ja311795d. Epub 2013 Apr 16. J Am Chem Soc. 2013. PMID: 23544844 Free PMC article.

8

A "turn-on" fluorescent sensor for methylglyoxal.

Wang T, Douglass EF Jr, Fitzgerald KJ, Spiegel DA. Wang T, et al. Among authors: spiegel da. J Am Chem Soc. 2013 Aug 21;135(33):12429-33. doi: 10.1021/ja406077j. Epub 2013 Aug 9. J Am Chem Soc. 2013. PMID: 23931147

9

Exploring binding and effector functions of natural human antibodies using synthetic immunomodulators.

Jakobsche CE, Parker CG, Tao RN, Kolesnikova MD, Douglass EF Jr, Spiegel DA. Jakobsche CE, et al. Among authors: spiegel da. ACS Chem Biol. 2013 Nov 15;8(11):2404-11. doi: 10.1021/cb4004942. Epub 2013 Sep 20. ACS Chem Biol. 2013. PMID: 24053626 Free PMC article.

10

Chemically synthesized molecules with the targeting and effector functions of antibodies.

McEnaney PJ, Fitzgerald KJ, Zhang AX, Douglass EF Jr, Shan W, Balog A, Kolesnikova MD, Spiegel DA. McEnaney PJ, et al. Among authors: spiegel da. J Am Chem Soc. 2014 Dec 31;136(52):18034-43. doi: 10.1021/ja509513c. Epub 2014 Dec 16. J Am Chem Soc. 2014. PMID: 25514603 Free PMC article.

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