Chen G - Search Results

1

Development of second-generation small-molecule RhoA inhibitors with enhanced water solubility, tissue potency, and significant in vivo efficacy.

Ma S, Deng J, Li B, Li X, Yan Z, Zhu J, Chen G, Wang Z, Jiang H, Miao L, Li J. Ma S, et al. Among authors: chen g. ChemMedChem. 2015 Jan;10(1):193-206. doi: 10.1002/cmdc.201402386. Epub 2014 Nov 5. ChemMedChem. 2015. PMID: 25377276

2

Elucidating inhibitory models of the inhibitors of epidermal growth factor receptor by docking and 3D-QSAR.

Chen G, Luo X, Zhu W, Luo C, Liu H, Puah CM, Chen K, Jiang H. Chen G, et al. Among authors: chen k. Bioorg Med Chem. 2004 May 1;12(9):2409-17. doi: 10.1016/j.bmc.2004.02.001. Bioorg Med Chem. 2004. PMID: 15080937

3

A new rapid and effective chemistry space filter in recognizing a druglike database.

Zheng S, Luo X, Chen G, Zhu W, Shen J, Chen K, Jiang H. Zheng S, et al. Among authors: chen k, chen g. J Chem Inf Model. 2005 Jul-Aug;45(4):856-62. doi: 10.1021/ci050031j. J Chem Inf Model. 2005. PMID: 16045278

4

Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features.

Chen L, Li J, Luo C, Liu H, Xu W, Chen G, Liew OW, Zhu W, Puah CM, Shen X, Jiang H. Chen L, et al. Among authors: chen g. Bioorg Med Chem. 2006 Dec 15;14(24):8295-306. doi: 10.1016/j.bmc.2006.09.014. Epub 2006 Oct 12. Bioorg Med Chem. 2006. PMID: 17046271 Free PMC article.

5

Novel non-peptide beta-secretase inhibitors derived from structure-based virtual screening and bioassay.

Xu W, Chen G, Liew OW, Zuo Z, Jiang H, Zhu W. Xu W, et al. Among authors: chen g. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3188-92. doi: 10.1016/j.bmcl.2009.04.113. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19447035

6

Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping.

Deng J, Li N, Liu H, Zuo Z, Liew OW, Xu W, Chen G, Tong X, Tang W, Zhu J, Zuo J, Jiang H, Yang CG, Li J, Zhu W. Deng J, et al. Among authors: chen g. J Med Chem. 2012 Jul 26;55(14):6278-93. doi: 10.1021/jm300146f. Epub 2012 Jul 11. J Med Chem. 2012. PMID: 22742496

7

Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system.

Liu Y, Qiu J, Wang Z, You W, Wu L, Ji C, Chen G. Liu Y, et al. Among authors: chen g. J Neurosurg. 2015 Oct;123(4):915-23. doi: 10.3171/2014.11.JNS132348. Epub 2015 Jan 23. J Neurosurg. 2015. PMID: 25614941

8

Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor‑β‑mediated epithelial‑mesenchymal transition.

Zhang Q, Han M, Wang W, Song Y, Chen G, Wang Z, Liang Z. Zhang Q, et al. Among authors: chen g. Oncol Rep. 2015 Apr;33(4):1851-9. doi: 10.3892/or.2015.3754. Epub 2015 Jan 27. Oncol Rep. 2015. PMID: 25632968

9

Evidence for the role of phosphatidylcholine-specific phospholipase in experimental subarachnoid hemorrhage in rats.

Li B, Li H, Wang Z, Wang Y, Gao A, Cui Y, Liu Y, Chen G. Li B, et al. Among authors: chen g. Exp Neurol. 2015 Oct;272:145-51. doi: 10.1016/j.expneurol.2015.02.031. Epub 2015 Mar 3. Exp Neurol. 2015. PMID: 25743218

10

Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage.

Zhang QQ, Wang WJ, Li J, Yang N, Chen G, Wang Z, Liang ZQ. Zhang QQ, et al. Among authors: chen g. Acta Pharmacol Sin. 2015 Sep;36(9):1113-25. doi: 10.1038/aps.2015.36. Epub 2015 Jun 22. Acta Pharmacol Sin. 2015. PMID: 26095040 Free PMC article.

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