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Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).
Cai K, Frederick RO, Kim JH, Reinen NM, Tonelli M, Markley JL. Cai K, et al. Among authors: kim jh. J Biol Chem. 2013 Oct 4;288(40):28755-70. doi: 10.1074/jbc.M113.482042. Epub 2013 Aug 12. J Biol Chem. 2013. PMID: 23940031 Free PMC article.
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