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Rare variant APOC3 R19X is associated with cardio-protective profiles in a diverse population-based survey as part of the Epidemiologic Architecture for Genes Linked to Environment Study.
Crawford DC, Dumitrescu L, Goodloe R, Brown-Gentry K, Boston J, McClellan B Jr, Sutcliffe C, Wiseman R, Baker P, Pericak-Vance MA, Scott WK, Allen M, Mayo P, Schnetz-Boutaud N, Dilks HH, Haines JL, Pollin TI. Crawford DC, et al. Among authors: dumitrescu l. Circ Cardiovasc Genet. 2014 Dec;7(6):848-53. doi: 10.1161/CIRCGENETICS.113.000369. Epub 2014 Nov 1. Circ Cardiovasc Genet. 2014. PMID: 25363704 Free PMC article.
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology.
Winfree RL, Nolan E, Dumitrescu L, Blennow K, Zetterberg H, Gifford KA, Pechman KR, Seto M, Petyuk VA, Wang Y, Schneider J, Bennett DA, Jefferson AL, Hohman TJ; Alzheimer’s Disease Neuroimaging Initiative*. Winfree RL, et al. Among authors: dumitrescu l. Mol Neurodegener. 2024 May 18;19(1):41. doi: 10.1186/s13024-024-00727-7. Mol Neurodegener. 2024. PMID: 38760857 Free PMC article.
TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia.
Winfree RL, Seto M, Dumitrescu L, Menon V, De Jager P, Wang Y, Schneider J, Bennett DA, Jefferson AL, Hohman TJ. Winfree RL, et al. Among authors: dumitrescu l. Acta Neuropathol. 2023 Jun;145(6):733-747. doi: 10.1007/s00401-023-02564-2. Epub 2023 Mar 25. Acta Neuropathol. 2023. PMID: 36966244 Free PMC article.
Novel CYP1B1-RMDN2 Alzheimer's disease locus identified by genome-wide association analysis of cerebral tau deposition on PET.
Nho K, Risacher SL, Apostolova L, Bice PJ, Brosch J, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, Sperling R, Hooli B, Shcherbinin S, Svaldi D, Jack CR, Jagust WJ, Landau S, Vasanthakumar A, Waring JF, Doré V, Laws SM, Masters CL, Porter T, Rowe CC, Villemagne VL, Dumitrescu L, Hohman TJ, Libby JB, Mormino E, Buckley RF, Johnson K, Yang HS, Petersen RC, Ramanan VK, Vemuri P, Cohen AD, Fan KH, Kamboh MI, Lopez OL, Bennett DA, Ali M, Benzinger T, Cruchaga C, Hobbs D, De Jager PL, Fujita M, Jadhav V, Lamb BT, Tsai AP, Castanho I, Mill J, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Neuroimaging Initiative – Department of Defense; Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study); Australian Imaging, Biomarker & Lifestyle Study (AIBL); Saykin AJ. Nho K, et al. Among authors: dumitrescu l. medRxiv [Preprint]. 2023 Mar 22:2023.02.27.23286048. doi: 10.1101/2023.02.27.23286048. medRxiv. 2023. PMID: 36993271 Free PMC article. Preprint.
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.
Ali M, Archer DB, Gorijala P, Western D, Timsina J, Fernández MV, Wang TC, Satizabal CL, Yang Q, Beiser AS, Wang R, Chen G, Gordon B, Benzinger TLS, Xiong C, Morris JC, Bateman RJ, Karch CM, McDade E, Goate A, Seshadri S, Mayeux RP, Sperling RA, Buckley RF, Johnson KA, Won HH, Jung SH, Kim HR, Seo SW, Kim HJ, Mormino E, Laws SM, Fan KH, Kamboh MI, Vemuri P, Ramanan VK, Yang HS, Wenzel A, Rajula HSR, Mishra A, Dufouil C, Debette S, Lopez OL, DeKosky ST, Tao F, Nagle MW; Knight Alzheimer Disease Research Center (Knight ADRC); Dominantly Inherited Alzheimer Network (DIAN); Alzheimer’s Disease Neuroimaging Initiative (ADNI); ADNI-DOD, A4 Study Team; Australian Imaging Biomarkers, Lifestyle (AIBL) Study; Hohman TJ, Sung YJ, Dumitrescu L, Cruchaga C. Ali M, et al. Among authors: dumitrescu l. Acta Neuropathol Commun. 2023 Apr 26;11(1):68. doi: 10.1186/s40478-023-01563-4. Acta Neuropathol Commun. 2023. PMID: 37101235 Free PMC article.
Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease.
Seto M, Dumitrescu L, Mahoney ER, Sclafani AM, De Jager PL, Menon V, Koran MEI, Robinson RA, Ruderfer DM, Cox NJ, Seyfried NT, Jefferson AL, Schneider JA, Bennett DA, Petyuk VA, Hohman TJ. Seto M, et al. Among authors: dumitrescu l. Neurobiol Aging. 2023 Jun;126:25-33. doi: 10.1016/j.neurobiolaging.2023.01.010. Epub 2023 Jan 26. Neurobiol Aging. 2023. PMID: 36905877 Free PMC article.
ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease.
Bartosch AMW, Youth EHH, Hansen S, Wu Y, Buchanan HM, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, Bennett DA, Young-Pearse TL, De Jager PL, Hohman TJ, Sproul AA, Teich AF. Bartosch AMW, et al. Among authors: dumitrescu lc. J Neurosci. 2024 Jan 17;44(3):e2324222023. doi: 10.1523/JNEUROSCI.2324-22.2023. J Neurosci. 2024. PMID: 38050142 Free PMC article.
Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition.
Bolton CJ, Steinbach M, Khan OA, Liu D, O'Malley J, Dumitrescu L, Peterson A, Jefferson AL, Hohman TJ, Zetterberg H, Gifford KA; Alzheimer’s Disease Neuroimaging Initiative. Bolton CJ, et al. Among authors: dumitrescu l. medRxiv [Preprint]. 2023 Nov 4:2023.11.03.23298051. doi: 10.1101/2023.11.03.23298051. medRxiv. 2023. PMID: 37961576 Free PMC article. Preprint.
Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.
Yan D, Hu B, Darst BF, Mukherjee S, Kunkle BW, Deming Y, Dumitrescu L, Wang Y, Naj A, Kuzma A, Zhao Y, Kang H, Johnson SC, Carlos C, Hohman TJ, Crane PK, Engelman CD; Alzheimer’s Disease Genetics Consortium (ADGC); Lu Q. Yan D, et al. Among authors: dumitrescu l. Elife. 2024 May 24;12:RP91360. doi: 10.7554/eLife.91360. Elife. 2024. PMID: 38787369 Free PMC article.
169 results