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Modulation of fibrillation of hIAPP core fragments by chemical modification of the peptide backbone.
Andreasen M, Nielsen SB, Mittag T, Bjerring M, Nielsen JT, Zhang S, Nielsen EH, Jeppesen M, Christiansen G, Besenbacher F, Dong M, Nielsen NC, Skrydstrup T, Otzen DE. Andreasen M, et al. Among authors: christiansen g. Biochim Biophys Acta. 2012 Feb;1824(2):274-85. doi: 10.1016/j.bbapap.2011.10.014. Epub 2011 Oct 29. Biochim Biophys Acta. 2012. PMID: 22064122
Scaffolded multimers of hIAPP(20-29) peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP(20-29) peptide fragment.
Christoffersen HF, Andreasen M, Zhang S, Nielsen EH, Christiansen G, Dong M, Skrydstrup T, Otzen DE. Christoffersen HF, et al. Among authors: christiansen g. Biochim Biophys Acta. 2015 Dec;1854(12):1890-1897. doi: 10.1016/j.bbapap.2015.08.005. Epub 2015 Aug 15. Biochim Biophys Acta. 2015. PMID: 26284878
Polymorphic fibrillation of the destabilized fourth fasciclin-1 domain mutant A546T of the Transforming growth factor-β-induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates.
Andreasen M, Nielsen SB, Runager K, Christiansen G, Nielsen NC, Enghild JJ, Otzen DE. Andreasen M, et al. Among authors: christiansen g. J Biol Chem. 2012 Oct 5;287(41):34730-42. doi: 10.1074/jbc.M112.379552. Epub 2012 Aug 14. J Biol Chem. 2012. PMID: 22893702 Free PMC article.
343 results