Roth BL - Search Results

1

The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo.

White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL. White KL, et al. Among authors: roth bl. J Pharmacol Exp Ther. 2015 Jan;352(1):98-109. doi: 10.1124/jpet.114.216820. Epub 2014 Oct 15. J Pharmacol Exp Ther. 2015. PMID: 25320048 Free PMC article.

2

1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist.

Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF. Nichols DE, et al. Among authors: roth bl. J Med Chem. 1994 Dec 9;37(25):4346-51. doi: 10.1021/jm00051a011. J Med Chem. 1994. PMID: 7996545

3

Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.

Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, Roth BL. Chavkin C, et al. Among authors: roth bl. J Pharmacol Exp Ther. 2004 Mar;308(3):1197-203. doi: 10.1124/jpet.103.059394. Epub 2004 Jan 8. J Pharmacol Exp Ther. 2004. PMID: 14718611

4

Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.

Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL. Yan F, et al. Among authors: roth bl. Biochemistry. 2005 Jun 21;44(24):8643-51. doi: 10.1021/bi050490d. Biochemistry. 2005. PMID: 15952771

5

Receptor systems: will mining the receptorome yield novel targets for pharmacotherapy?

Roth BL. Roth BL. Pharmacol Ther. 2005 Oct;108(1):59-64. doi: 10.1016/j.pharmthera.2005.06.013. Pharmacol Ther. 2005. PMID: 16083965 Review.

6

Bioisosteric modification of salvinorin A, a potent and selective kappa-opioid receptor agonist.

Stewart DJ, Fahmy H, Roth BL, Yan F, Zjawiony JK. Stewart DJ, et al. Among authors: roth bl. Arzneimittelforschung. 2006;56(4):269-75. doi: 10.1055/s-0031-1296720. Arzneimittelforschung. 2006. PMID: 16724512

7

Functional selectivity and classical concepts of quantitative pharmacology.

Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Urban JD, et al. Among authors: roth bl. J Pharmacol Exp Ther. 2007 Jan;320(1):1-13. doi: 10.1124/jpet.106.104463. Epub 2006 Jun 27. J Pharmacol Exp Ther. 2007. PMID: 16803859 Review.

8

WAY-100635 is a potent dopamine D4 receptor agonist.

Chemel BR, Roth BL, Armbruster B, Watts VJ, Nichols DE. Chemel BR, et al. Among authors: roth bl. Psychopharmacology (Berl). 2006 Oct;188(2):244-51. doi: 10.1007/s00213-006-0490-4. Epub 2006 Aug 17. Psychopharmacology (Berl). 2006. PMID: 16915381

9

Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B.

Bikbulatov RV, Yan F, Roth BL, Zjawiony JK. Bikbulatov RV, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2229-32. doi: 10.1016/j.bmcl.2007.01.100. Epub 2007 Feb 2. Bioorg Med Chem Lett. 2007. PMID: 17303418 Free PMC article.

10

N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy.

Béguin C, Potter DN, Dinieri JA, Munro TA, Richards MR, Paine TA, Berry L, Zhao Z, Roth BL, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM. Béguin C, et al. Among authors: roth bl. J Pharmacol Exp Ther. 2008 Jan;324(1):188-95. doi: 10.1124/jpet.107.129023. Epub 2007 Oct 19. J Pharmacol Exp Ther. 2008. PMID: 17951511

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