Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei.
Balogun EO, Inaoka DK, Shiba T, Tsuge C, May B, Sato T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PAM, Watanabe YI, Moore AL, Harada S, Kita K.
Balogun EO, et al. Among authors: aoki t.
FASEB J. 2019 Nov;33(11):13002-13013. doi: 10.1096/fj.201901342R. Epub 2019 Sep 16.
FASEB J. 2019.
PMID: 31525300
Although the EC(50) of compound 17b against trypanosome cells was 1.77 M, it had no effect on cultured human cells, even at 50 M.-Balogun, E. O., Inaoka, D. K., Shiba, T., Tsuge, C., May, B., Sato, T., Kido, Y., Nara, T., Aoki, T., Honma, T …
Although the EC(50) of compound 17b against trypanosome cells was 1.77 M, it had no effect on cultured human cells, even at 50 M.-Balogun, E …