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The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells.
Berghauser Pont LM, Spoor JK, Venkatesan S, Swagemakers S, Kloezeman JJ, Dirven CM, van der Spek PJ, Lamfers ML, Leenstra S. Berghauser Pont LM, et al. Among authors: venkatesan s. Genes Cancer. 2014 Nov;5(11-12):445-59. doi: 10.18632/genesandcancer.42. Genes Cancer. 2014. PMID: 25568669 Free PMC article.
TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2.
Venkatesan S, Hoogstraat M, Caljouw E, Pierson T, Spoor JK, Zeneyedpour L, Dubbink HJ, Dekker LJ, van der Kaaij M, Kloezeman J, Berghauser Pont LM, Besselink NJ, Luider TM, Joore J, Martens JW, Lamfers ML, Sleijfer S, Leenstra S. Venkatesan S, et al. Oncotarget. 2016 Sep 6;7(36):58435-58444. doi: 10.18632/oncotarget.11205. Oncotarget. 2016. PMID: 27533080 Free PMC article.
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
Kanu N, Cerone MA, Goh G, Zalmas LP, Bartkova J, Dietzen M, McGranahan N, Rogers R, Law EK, Gromova I, Kschischo M, Walton MI, Rossanese OW, Bartek J, Harris RS, Venkatesan S, Swanton C. Kanu N, et al. Among authors: venkatesan s. Genome Biol. 2016 Sep 15;17(1):185. doi: 10.1186/s13059-016-1042-9. Genome Biol. 2016. PMID: 27634334 Free PMC article.
Constraints in cancer evolution.
Venkatesan S, Birkbak NJ, Swanton C. Venkatesan S, et al. Biochem Soc Trans. 2017 Feb 8;45(1):1-13. doi: 10.1042/BST20160229. Biochem Soc Trans. 2017. PMID: 28202655 Review.
Evolutionary dynamics in pre-invasive neoplasia.
Abbosh C, Venkatesan S, Janes SM, Fitzgerald RC, Swanton C. Abbosh C, et al. Among authors: venkatesan s. Curr Opin Syst Biol. 2017 Apr;2:1-8. doi: 10.1016/j.coisb.2017.02.009. Curr Opin Syst Biol. 2017. PMID: 30603736 Free PMC article.
577 results