Giclas PC - Search Results

1

Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans.

Shen L, Frazer-Abel A, Reynolds PR, Giclas PC, Chappell A, Pangburn MK, Younis H, Henry SP. Shen L, et al. Among authors: giclas pc. J Pharmacol Exp Ther. 2014 Dec;351(3):709-17. doi: 10.1124/jpet.114.219378. Epub 2014 Oct 9. J Pharmacol Exp Ther. 2014. PMID: 25301170 Clinical Trial.

2

Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: potential mechanism of action.

Henry SP, Giclas PC, Leeds J, Pangburn M, Auletta C, Levin AA, Kornbrust DJ. Henry SP, et al. Among authors: giclas pc. J Pharmacol Exp Ther. 1997 May;281(2):810-6. J Pharmacol Exp Ther. 1997. PMID: 9152389

3

Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2'-O-Methoxyethyl Modified Antisense Oligonucleotide.

Shen L, Engelhardt JA, Hung G, Yee J, Kikkawa R, Matson J, Tayefeh B, Machemer T, Giclas PC, Henry SP. Shen L, et al. Among authors: giclas pc. Nucleic Acid Ther. 2016 Aug;26(4):236-49. doi: 10.1089/nat.2015.0584. Epub 2016 May 3. Nucleic Acid Ther. 2016. PMID: 27140858

4

Mechanism of alternative complement pathway dysregulation by a phosphorothioate oligonucleotide in monkey and human serum.

Henry SP, Jagels MA, Hugli TE, Manalili S, Geary RS, Giclas PC, Levin AA. Henry SP, et al. Among authors: giclas pc. Nucleic Acid Ther. 2014 Oct;24(5):326-35. doi: 10.1089/nat.2014.0491. Epub 2014 Aug 5. Nucleic Acid Ther. 2014. PMID: 25093529

5

Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide.

Henry SP, Beattie G, Yeh G, Chappel A, Giclas P, Mortari A, Jagels MA, Kornbrust DJ, Levin AA. Henry SP, et al. Int Immunopharmacol. 2002 Nov;2(12):1657-66. doi: 10.1016/s1567-5769(02)00142-x. Int Immunopharmacol. 2002. PMID: 12469940

6

Update on laboratory tests for the diagnosis and differentiation of hereditary angioedema and acquired angioedema.

Frazer-Abel A, Giclas PC. Frazer-Abel A, et al. Among authors: giclas pc. Allergy Asthma Proc. 2011 Sep-Oct;32 Suppl 1:17-21. doi: 10.2500/aap.2011.32.3472. Allergy Asthma Proc. 2011. PMID: 22195757

7

Complement Activation in Patients with Focal Segmental Glomerulosclerosis.

Thurman JM, Wong M, Renner B, Frazer-Abel A, Giclas PC, Joy MS, Jalal D, Radeva MK, Gassman J, Gipson DS, Kaskel F, Friedman A, Trachtman H. Thurman JM, et al. Among authors: giclas pc. PLoS One. 2015 Sep 3;10(9):e0136558. doi: 10.1371/journal.pone.0136558. eCollection 2015. PLoS One. 2015. PMID: 26335102 Free PMC article.

8

Patients with nontuberculous mycobacterial lung disease exhibit unique body and immune phenotypes.

Kartalija M, Ovrutsky AR, Bryan CL, Pott GB, Fantuzzi G, Thomas J, Strand MJ, Bai X, Ramamoorthy P, Rothman MS, Nagabhushanam V, McDermott M, Levin AR, Frazer-Abel A, Giclas PC, Korner J, Iseman MD, Shapiro L, Chan ED. Kartalija M, et al. Among authors: giclas pc. Am J Respir Crit Care Med. 2013 Jan 15;187(2):197-205. doi: 10.1164/rccm.201206-1035OC. Epub 2012 Nov 9. Am J Respir Crit Care Med. 2013. PMID: 23144328 Free PMC article.

9

Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.

Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Shultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW. Park JW, et al. Among authors: giclas pc. Am J Respir Crit Care Med. 2004 Mar 15;169(6):726-32. doi: 10.1164/rccm.200307-1042OC. Epub 2003 Dec 30. Am J Respir Crit Care Med. 2004. PMID: 14701711

10

Inhibition of complement activation decreases airway inflammation and hyperresponsiveness.

Taube C, Rha YH, Takeda K, Park JW, Joetham A, Balhorn A, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Taube C, et al. Among authors: giclas pc. Am J Respir Crit Care Med. 2003 Dec 1;168(11):1333-41. doi: 10.1164/rccm.200306-739OC. Epub 2003 Sep 18. Am J Respir Crit Care Med. 2003. PMID: 14500265

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