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Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.
Pathangey LB, McCurry DB, Gendler SJ, Dominguez AL, Gorman JE, Pathangey G, Mihalik LA, Dang Y, Disis ML, Cohen PA. Pathangey LB, et al. Among authors: gendler sj. Oncotarget. 2017 Feb 14;8(7):10785-10808. doi: 10.18632/oncotarget.13911. Oncotarget. 2017. PMID: 27974697 Free PMC article.
MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.
Lakshminarayanan V, Supekar NT, Wei J, McCurry DB, Dueck AC, Kosiorek HE, Trivedi PP, Bradley JM, Madsen CS, Pathangey LB, Hoelzinger DB, Wolfert MA, Boons GJ, Cohen PA, Gendler SJ. Lakshminarayanan V, et al. Among authors: gendler sj. PLoS One. 2016 Jan 20;11(1):e0145920. doi: 10.1371/journal.pone.0145920. eCollection 2016. PLoS One. 2016. PMID: 26788922 Free PMC article.
Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine.
Lakshminarayanan V, Thompson P, Wolfert MA, Buskas T, Bradley JM, Pathangey LB, Madsen CS, Cohen PA, Gendler SJ, Boons GJ. Lakshminarayanan V, et al. Among authors: gendler sj. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):261-6. doi: 10.1073/pnas.1115166109. Epub 2011 Dec 14. Proc Natl Acad Sci U S A. 2012. PMID: 22171012 Free PMC article.
158 results