Lombardo MN - Search Results

1

Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.

Lamb KM, Lombardo MN, Alverson J, Priestley ND, Wright DL, Anderson AC. Lamb KM, et al. Among authors: lombardo mn. Antimicrob Agents Chemother. 2014 Dec;58(12):7484-91. doi: 10.1128/AAC.03555-14. Epub 2014 Oct 6. Antimicrob Agents Chemother. 2014. PMID: 25288083 Free PMC article.

2

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley ND, Obach RS, Wright DL. Lombardo MN, et al. Drug Metab Dispos. 2019 Sep;47(9):995-1003. doi: 10.1124/dmd.119.086504. Epub 2019 Jun 14. Drug Metab Dispos. 2019. PMID: 31201212 Free PMC article.

3

Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.

Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Frey KM, et al. Among authors: lombardo mn. J Mol Biol. 2009 Apr 17;387(5):1298-308. doi: 10.1016/j.jmb.2009.02.045. Epub 2009 Feb 26. J Mol Biol. 2009. PMID: 19249312 Free PMC article.

4

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.

Frey KM, Lombardo MN, Wright DL, Anderson AC. Frey KM, et al. Among authors: lombardo mn. J Struct Biol. 2010 Apr;170(1):93-7. doi: 10.1016/j.jsb.2009.12.011. Epub 2009 Dec 21. J Struct Biol. 2010. PMID: 20026215 Free PMC article.

5

Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.

G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC. G-Dayanandan N, et al. Among authors: lombardo mn. J Med Chem. 2014 Mar 27;57(6):2643-56. doi: 10.1021/jm401916j. Epub 2014 Mar 6. J Med Chem. 2014. PMID: 24568657 Free PMC article.

6

Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.

Heidari-Torkabadi H, Che T, Lombardo MN, Wright DL, Anderson AC, Carey PR. Heidari-Torkabadi H, et al. Among authors: lombardo mn. Biochemistry. 2015 May 5;54(17):2719-26. doi: 10.1021/acs.biochem.5b00202. Epub 2015 Apr 22. Biochemistry. 2015. PMID: 25871808

7

Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC. Lombardo MN, et al. ACS Infect Dis. 2016 Feb 12;2(2):149-56. doi: 10.1021/acsinfecdis.5b00129. Epub 2016 Jan 4. ACS Infect Dis. 2016. PMID: 27624966 Free PMC article.

8

Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates.

Cammarata M, Thyer R, Lombardo M, Anderson A, Wright D, Ellington A, Brodbelt JS. Cammarata M, et al. Chem Sci. 2017 May 1;8(5):4062-4072. doi: 10.1039/c6sc05235e. Epub 2017 Mar 28. Chem Sci. 2017. PMID: 29967675 Free PMC article.

9

Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.

Reeve SM, Lombardo MN, Anderson AC. Reeve SM, et al. Among authors: lombardo mn. Future Microbiol. 2015;10(11):1727-33. doi: 10.2217/fmb.15.78. Epub 2015 Oct 30. Future Microbiol. 2015. PMID: 26516790 Free PMC article. Review.

10

Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.

Scocchera E, Reeve SM, Keshipeddy S, Lombardo MN, Hajian B, Sochia AE, Alverson JB, Priestley ND, Anderson AC, Wright DL. Scocchera E, et al. Among authors: lombardo mn. ACS Med Chem Lett. 2016 May 5;7(7):692-6. doi: 10.1021/acsmedchemlett.6b00120. eCollection 2016 Jul 14. ACS Med Chem Lett. 2016. PMID: 27437079 Free PMC article.

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