Anderson AC - Search Results

1

Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.

Lamb KM, Lombardo MN, Alverson J, Priestley ND, Wright DL, Anderson AC. Lamb KM, et al. Among authors: anderson ac. Antimicrob Agents Chemother. 2014 Dec;58(12):7484-91. doi: 10.1128/AAC.03555-14. Epub 2014 Oct 6. Antimicrob Agents Chemother. 2014. PMID: 25288083 Free PMC article.

2

Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.

Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Liu J, et al. Among authors: anderson ac. Chem Biol. 2008 Sep 22;15(9):990-6. doi: 10.1016/j.chembiol.2008.07.013. Chem Biol. 2008. PMID: 18804036 Free PMC article.

3

Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase.

Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC. Beierlein JM, et al. Among authors: anderson ac. J Med Chem. 2008 Dec 11;51(23):7532-40. doi: 10.1021/jm800776a. J Med Chem. 2008. PMID: 19007108 Free PMC article.

4

Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors.

Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Liu J, et al. Among authors: anderson ac. Chem Biol Drug Des. 2009 Jan;73(1):62-74. doi: 10.1111/j.1747-0285.2008.00745.x. Chem Biol Drug Des. 2009. PMID: 19152636 Free PMC article.

5

Towards new antifolates targeting eukaryotic opportunistic infections.

Liu J, Bolstad DB, Bolstad ES, Wright DL, Anderson AC. Liu J, et al. Among authors: anderson ac. Eukaryot Cell. 2009 Apr;8(4):483-6. doi: 10.1128/EC.00298-08. Epub 2009 Jan 23. Eukaryot Cell. 2009. PMID: 19168759 Free PMC article.

6

Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.

Sundstrom TJ, Anderson AC, Wright DL. Sundstrom TJ, et al. Among authors: anderson ac. Org Biomol Chem. 2009 Mar 7;7(5):840-50. doi: 10.1039/b819067b. Epub 2009 Jan 8. Org Biomol Chem. 2009. PMID: 19225663 Review.

7

Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.

Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Frey KM, et al. Among authors: anderson ac. J Mol Biol. 2009 Apr 17;387(5):1298-308. doi: 10.1016/j.jmb.2009.02.045. Epub 2009 Feb 26. J Mol Biol. 2009. PMID: 19249312 Free PMC article.

8

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.

Frey KM, Lombardo MN, Wright DL, Anderson AC. Frey KM, et al. Among authors: anderson ac. J Struct Biol. 2010 Apr;170(1):93-7. doi: 10.1016/j.jsb.2009.12.011. Epub 2009 Dec 21. J Struct Biol. 2010. PMID: 20026215 Free PMC article.

9

Antifolate agents: a patent review (2006 - 2010).

Wright DL, Anderson AC. Wright DL, et al. Among authors: anderson ac. Expert Opin Ther Pat. 2011 Sep;21(9):1293-308. doi: 10.1517/13543776.2011.587804. Epub 2011 May 27. Expert Opin Ther Pat. 2011. PMID: 21619471 Free PMC article. Review.

10

Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes.

Viswanathan K, Frey KM, Scocchera EW, Martin BD, Swain Iii PW, Alverson JB, Priestley ND, Anderson AC, Wright DL. Viswanathan K, et al. Among authors: anderson ac. PLoS One. 2012;7(2):e29434. doi: 10.1371/journal.pone.0029434. Epub 2012 Feb 7. PLoS One. 2012. PMID: 22347365 Free PMC article.

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