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Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.
Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC. Takakusagi Y, et al. Among authors: kesarwala ah. PLoS One. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995. eCollection 2014. PLoS One. 2014. PMID: 25254649 Free PMC article.
Oxidative stress in oral diseases.
Kesarwala AH, Krishna MC, Mitchell JB. Kesarwala AH, et al. Oral Dis. 2016 Jan;22(1):9-18. doi: 10.1111/odi.12300. Epub 2015 Jan 19. Oral Dis. 2016. PMID: 25417961 Free PMC article. Review.
NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay.
Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA. Ridnour LA, et al. Among authors: kesarwala ah. Cancer Res. 2015 Jul 15;75(14):2788-99. doi: 10.1158/0008-5472.CAN-14-3011. Epub 2015 May 19. Cancer Res. 2015. PMID: 25990221 Free PMC article.
Simple Esterification of [1-13C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine Production.
AbuSalim JE, Yamamoto K, Miura N, Blackman B, Brender JR, Mushti C, Seki T, Camphausen KA, Swenson RE, Krishna MC, Kesarwala AH. AbuSalim JE, et al. Among authors: kesarwala ah. ACS Chem Biol. 2021 Nov 19;16(11):2144-2150. doi: 10.1021/acschembio.1c00561. Epub 2021 Sep 23. ACS Chem Biol. 2021. PMID: 34554724 Free PMC article.
Signaling and stress: The redox landscape in NOS2 biology.
Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD, Glynn S, Fukuto JM, Wink DA, Miranda KM. Thomas DD, et al. Among authors: kesarwala ah. Free Radic Biol Med. 2015 Oct;87:204-25. doi: 10.1016/j.freeradbiomed.2015.06.002. Epub 2015 Jun 24. Free Radic Biol Med. 2015. PMID: 26117324 Free PMC article. Review.
52 results