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Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.
Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC. Takakusagi Y, et al. Among authors: gillies rj. PLoS One. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995. eCollection 2014. PLoS One. 2014. PMID: 25254649 Free PMC article.
Imaging pH and metastasis.
Hashim AI, Zhang X, Wojtkowiak JW, Martinez GV, Gillies RJ. Hashim AI, et al. Among authors: gillies rj. NMR Biomed. 2011 Jul;24(6):582-91. doi: 10.1002/nbm.1644. Epub 2011 Mar 8. NMR Biomed. 2011. PMID: 21387439 Free PMC article. Review.
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.
Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Wojtkowiak JW, et al. Among authors: gillies rj. Cancer Res. 2012 Aug 15;72(16):3938-47. doi: 10.1158/0008-5472.CAN-11-3881. Epub 2012 Jun 19. Cancer Res. 2012. PMID: 22719070 Free PMC article.
Autophagy on acid.
Wojtkowiak JW, Gillies RJ. Wojtkowiak JW, et al. Among authors: gillies rj. Autophagy. 2012 Nov;8(11):1688-9. doi: 10.4161/auto.21501. Epub 2012 Aug 9. Autophagy. 2012. PMID: 22874557 Free PMC article.
Targeting the metabolic microenvironment of tumors.
Bailey KM, Wojtkowiak JW, Hashim AI, Gillies RJ. Bailey KM, et al. Among authors: gillies rj. Adv Pharmacol. 2012;65:63-107. doi: 10.1016/B978-0-12-397927-8.00004-X. Adv Pharmacol. 2012. PMID: 22959024 Free PMC article. Review.
Acidity generated by the tumor microenvironment drives local invasion.
Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Estrella V, et al. Among authors: gillies rj. Cancer Res. 2013 Mar 1;73(5):1524-35. doi: 10.1158/0008-5472.CAN-12-2796. Epub 2013 Jan 3. Cancer Res. 2013. PMID: 23288510 Free PMC article.
416 results