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Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.
Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC. Takakusagi Y, et al. Among authors: choudhuri r. PLoS One. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995. eCollection 2014. PLoS One. 2014. PMID: 25254649 Free PMC article.
EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.
Matsumoto S, Saito K, Yasui H, Morris HD, Munasinghe JP, Lizak M, Merkle H, Ardenkjaer-Larsen JH, Choudhuri R, Devasahayam N, Subramanian S, Koretsky AP, Mitchell JB, Krishna MC. Matsumoto S, et al. Among authors: choudhuri r. Magn Reson Med. 2013 May;69(5):1443-50. doi: 10.1002/mrm.24355. Epub 2012 Jun 12. Magn Reson Med. 2013. PMID: 22692861 Free PMC article.
Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI.
Matsumoto S, Yasui H, Batra S, Kinoshita Y, Bernardo M, Munasinghe JP, Utsumi H, Choudhuri R, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC. Matsumoto S, et al. Among authors: choudhuri r. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17898-903. doi: 10.1073/pnas.0908447106. Epub 2009 Oct 6. Proc Natl Acad Sci U S A. 2009. PMID: 19815528 Free PMC article.
Inhibition of adipogenesis by Tempol in 3T3-L1 cells.
Samuni Y, Cook JA, Choudhuri R, Degraff W, Sowers AL, Krishna MC, Mitchell JB. Samuni Y, et al. Among authors: choudhuri r. Free Radic Biol Med. 2010 Aug 15;49(4):667-73. doi: 10.1016/j.freeradbiomed.2010.05.028. Epub 2010 Jun 16. Free Radic Biol Med. 2010. PMID: 20561604 Free PMC article.
Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma.
Yamamoto K, Brender JR, Seki T, Kishimoto S, Oshima N, Choudhuri R, Adler SS, Jagoda EM, Saito K, Devasahayam N, Choyke PL, Mitchell JB, Krishna MC. Yamamoto K, et al. Among authors: choudhuri r. Cancer Res. 2020 Jun 1;80(11):2087-2093. doi: 10.1158/0008-5472.CAN-19-0928. Epub 2020 Apr 3. Cancer Res. 2020. PMID: 32245793 Free PMC article.
53 results