Popov N - Search Results

1

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M. Peter S, et al. Among authors: popov n. EMBO Mol Med. 2014 Dec;6(12):1525-41. doi: 10.15252/emmm.201403927. EMBO Mol Med. 2014. PMID: 25253726 Free PMC article.

2

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.

Adhikary S, Marinoni F, Hock A, Hulleman E, Popov N, Beier R, Bernard S, Quarto M, Capra M, Goettig S, Kogel U, Scheffner M, Helin K, Eilers M. Adhikary S, et al. Among authors: popov n. Cell. 2005 Nov 4;123(3):409-21. doi: 10.1016/j.cell.2005.08.016. Cell. 2005. PMID: 16269333 Free article.

3

The ubiquitin-specific protease USP28 is required for MYC stability.

Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M. Popov N, et al. Nat Cell Biol. 2007 Jul;9(7):765-74. doi: 10.1038/ncb1601. Epub 2007 Jun 10. Nat Cell Biol. 2007. PMID: 17558397

4

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.

Popov N, Herold S, Llamazares M, Schülein C, Eilers M. Popov N, et al. Cell Cycle. 2007 Oct 1;6(19):2327-31. doi: 10.4161/cc.6.19.4804. Epub 2007 Jul 26. Cell Cycle. 2007. PMID: 17873522

5

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.

Otto T, Horn S, Brockmann M, Eilers U, Schüttrumpf L, Popov N, Kenney AM, Schulte JH, Beijersbergen R, Christiansen H, Berwanger B, Eilers M. Otto T, et al. Among authors: popov n. Cancer Cell. 2009 Jan 6;15(1):67-78. doi: 10.1016/j.ccr.2008.12.005. Cancer Cell. 2009. PMID: 19111882 Free article.

6

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.

Popov N, Schülein C, Jaenicke LA, Eilers M. Popov N, et al. Nat Cell Biol. 2010 Oct;12(10):973-81. doi: 10.1038/ncb2104. Epub 2010 Sep 19. Nat Cell Biol. 2010. PMID: 20852628

7

PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity.

Schülein C, Eilers M, Popov N. Schülein C, et al. Among authors: popov n. FEBS Lett. 2011 Jul 21;585(14):2151-7. doi: 10.1016/j.febslet.2011.05.036. Epub 2011 May 24. FEBS Lett. 2011. PMID: 21620836 Free article.

8

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.

Diefenbacher ME, Popov N, Blake SM, Schülein-Völk C, Nye E, Spencer-Dene B, Jaenicke LA, Eilers M, Behrens A. Diefenbacher ME, et al. Among authors: popov n. J Clin Invest. 2014 Aug;124(8):3407-18. doi: 10.1172/JCI73733. Epub 2014 Jun 24. J Clin Invest. 2014. PMID: 24960159 Free PMC article.

9

Dual regulation of Fbw7 function and oncogenic transformation by Usp28.

Schülein-Völk C, Wolf E, Zhu J, Xu W, Taranets L, Hellmann A, Jänicke LA, Diefenbacher ME, Behrens A, Eilers M, Popov N. Schülein-Völk C, et al. Among authors: popov n. Cell Rep. 2014 Nov 6;9(3):1099-109. doi: 10.1016/j.celrep.2014.09.057. Epub 2014 Oct 30. Cell Rep. 2014. PMID: 25437563 Free article.

10

Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.

Diefenbacher ME, Chakraborty A, Blake SM, Mitter R, Popov N, Eilers M, Behrens A. Diefenbacher ME, et al. Among authors: popov n. Cancer Res. 2015 Apr 1;75(7):1181-6. doi: 10.1158/0008-5472.CAN-14-1726. Epub 2015 Feb 25. Cancer Res. 2015. PMID: 25716680 Free PMC article.

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