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The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
Liachko NF, McMillan PJ, Strovas TJ, Loomis E, Greenup L, Murrell JR, Ghetti B, Raskind MA, Montine TJ, Bird TD, Leverenz JB, Kraemer BC. Liachko NF, et al. Among authors: mcmillan pj. PLoS Genet. 2014 Dec 4;10(12):e1004803. doi: 10.1371/journal.pgen.1004803. eCollection 2014 Dec. PLoS Genet. 2014. PMID: 25473830 Free PMC article.
High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration.
Wheeler JM, McMillan PJ, Hawk M, Iba M, Robinson L, Xu GJ, Dombroski BA, Jeong D, Dichter MA, Juul H, Loomis E, Raskind M, Leverenz JB, Trojanowski JQ, Lee VM, Schellenberg GD, Kraemer BC. Wheeler JM, et al. Among authors: mcmillan pj. Acta Neuropathol Commun. 2015 Jun 4;3:33. doi: 10.1186/s40478-015-0210-6. Acta Neuropathol Commun. 2015. PMID: 26041339 Free PMC article.
Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction.
Huber BR, Meabon JS, Hoffer ZS, Zhang J, Hoekstra JG, Pagulayan KF, McMillan PJ, Mayer CL, Banks WA, Kraemer BC, Raskind MA, McGavern DB, Peskind ER, Cook DG. Huber BR, et al. Among authors: mcmillan pj. Neuroscience. 2016 Apr 5;319:206-20. doi: 10.1016/j.neuroscience.2016.01.022. Epub 2016 Jan 14. Neuroscience. 2016. PMID: 26777891 Free PMC article.
The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.
Liachko NF, Saxton AD, McMillan PJ, Strovas TJ, Currey HN, Taylor LM, Wheeler JM, Oblak AL, Ghetti B, Montine TJ, Keene CD, Raskind MA, Bird TD, Kraemer BC. Liachko NF, et al. Among authors: mcmillan pj. Acta Neuropathol. 2016 Oct;132(4):545-61. doi: 10.1007/s00401-016-1600-y. Epub 2016 Jul 29. Acta Neuropathol. 2016. PMID: 27473149 Free PMC article.
Tau tubulin kinases in proteinopathy.
Taylor LM, McMillan PJ, Kraemer BC, Liachko NF. Taylor LM, et al. Among authors: mcmillan pj. FEBS J. 2019 Jul;286(13):2434-2446. doi: 10.1111/febs.14866. Epub 2019 May 22. FEBS J. 2019. PMID: 31034749 Free PMC article. Review.
125 results