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Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles.
List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ. List EO, et al. Among authors: lebrasseur nk. Endocrinology. 2014 May;155(5):1793-805. doi: 10.1210/en.2013-2086. Epub 2014 Feb 11. Endocrinology. 2014. PMID: 24517230 Free PMC article.
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. Zhu Y, et al. Among authors: lebrasseur nk. Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22. Aging Cell. 2015. PMID: 25754370 Free PMC article.
Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease.
Schafer MJ, Atkinson EJ, Vanderboom PM, Kotajarvi B, White TA, Moore MM, Bruce CJ, Greason KL, Suri RM, Khosla S, Miller JD, Bergen HR 3rd, LeBrasseur NK. Schafer MJ, et al. Among authors: lebrasseur nk. Cell Metab. 2016 Jun 14;23(6):1207-1215. doi: 10.1016/j.cmet.2016.05.023. Cell Metab. 2016. PMID: 27304512 Free PMC article.
Identification of Senescent Cells in the Bone Microenvironment.
Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S. Farr JN, et al. Among authors: lebrasseur nk. J Bone Miner Res. 2016 Nov;31(11):1920-1929. doi: 10.1002/jbmr.2892. Epub 2016 Oct 24. J Bone Miner Res. 2016. PMID: 27341653 Free PMC article.
Cellular senescence mediates fibrotic pulmonary disease.
Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK. Schafer MJ, et al. Among authors: lebrasseur nk. Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532. Nat Commun. 2017. PMID: 28230051 Free PMC article.
The Impact of Frailty on Patient-Centered Outcomes Following Aortic Valve Replacement.
Kotajarvi BR, Schafer MJ, Atkinson EJ, Traynor MM, Bruce CJ, Greason KL, Suri RM, Miller JD, LeBrasseur NK. Kotajarvi BR, et al. Among authors: lebrasseur nk. J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):917-921. doi: 10.1093/gerona/glx038. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28329140 Free PMC article.
Targeting cellular senescence prevents age-related bone loss in mice.
Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S. Farr JN, et al. Among authors: lebrasseur nk. Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Nat Med. 2017. PMID: 28825716 Free PMC article.
192 results