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Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.
Moutal A, Wang Y, Yang X, Ji Y, Luo S, Dorame A, Bellampalli SS, Chew LA, Cai S, Dustrude ET, Keener JE, Marty MT, Vanderah TW, Khanna R. Moutal A, et al. Pain. 2017 Nov;158(11):2203-2221. doi: 10.1097/j.pain.0000000000001026. Pain. 2017. PMID: 28767512 Free PMC article.
Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamide and safinamide.
Park KD, Yang XF, Dustrude ET, Wang Y, Ripsch MS, White FA, Khanna R, Kohn H. Park KD, et al. Among authors: yang xf. ACS Chem Neurosci. 2015 Feb 18;6(2):316-30. doi: 10.1021/cn5002182. Epub 2014 Dec 9. ACS Chem Neurosci. 2015. PMID: 25418676 Free PMC article.
(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, Porreca F, Khanna R. Moutal A, et al. Pain. 2016 Jul;157(7):1448-1463. doi: 10.1097/j.pain.0000000000000555. Pain. 2016. PMID: 26967696 Free PMC article.
Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Torregrosa R, Yang XF, Dustrude ET, Cummins TR, Khanna R, Kohn H. Torregrosa R, et al. Among authors: yang xf. Bioorg Med Chem. 2015 Jul 1;23(13):3655-66. doi: 10.1016/j.bmc.2015.04.014. Epub 2015 Apr 11. Bioorg Med Chem. 2015. PMID: 25922183 Free PMC article.
1,047 results