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Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists.
Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec AS, James MJ, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM, Smith AB 3rd, Brunden KR, Ballatore C. Wang X, et al. Among authors: herbst robinson k. ACS Med Chem Lett. 2014 Jul 24;5(9):1015-20. doi: 10.1021/ml5002085. eCollection 2014 Sep 11. ACS Med Chem Lett. 2014. PMID: 25221659 Free PMC article.
Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.
Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ, Smith AB 3rd, Lee VM, Ballatore C, Brunden KR. Soper JH, et al. Among authors: herbst robinson k. ACS Chem Neurosci. 2012 Nov 21;3(11):928-40. doi: 10.1021/cn3000795. Epub 2012 Jul 27. ACS Chem Neurosci. 2012. PMID: 23173073 Free PMC article.