Sebti SM - Search Results

1

Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt.

Kim YB, Kang CW, Ranatunga S, Yang H, Sebti SM, Del Valle JR. Kim YB, et al. Among authors: sebti sm. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4650-4653. doi: 10.1016/j.bmcl.2014.08.040. Epub 2014 Aug 28. Bioorg Med Chem Lett. 2014. PMID: 25205195 Free PMC article.

2

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction.

Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR. Kim YB, et al. Among authors: sebti sm. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5961-5. doi: 10.1016/j.bmcl.2012.07.050. Epub 2012 Jul 24. Bioorg Med Chem Lett. 2012. PMID: 22901384 Free PMC article.

3

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.

Lawrence HR, Martin MP, Luo Y, Pireddu R, Yang H, Gevariya H, Ozcan S, Zhu JY, Kendig R, Rodriguez M, Elias R, Cheng JQ, Sebti SM, Schonbrunn E, Lawrence NJ. Lawrence HR, et al. Among authors: sebti sm. J Med Chem. 2012 Sep 13;55(17):7392-7416. doi: 10.1021/jm300334d. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22803810 Free PMC article.

4

The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells.

Yang H, Xiang S, Kazi A, Sebti SM. Yang H, et al. Among authors: sebti sm. J Biol Chem. 2020 Mar 6;295(10):3055-3063. doi: 10.1074/jbc.RA119.011930. Epub 2020 Jan 30. J Biol Chem. 2020. PMID: 32001619 Free PMC article.

5

Design and synthesis of AApeptides: a new class of peptide mimics.

Hu Y, Li X, Sebti SM, Chen J, Cai J. Hu Y, et al. Among authors: sebti sm. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1469-71. doi: 10.1016/j.bmcl.2011.01.005. Epub 2011 Jan 7. Bioorg Med Chem Lett. 2011. PMID: 21292484

6

Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.

Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu JY, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM. Li R, et al. Among authors: sebti sm. J Med Chem. 2012 Mar 8;55(5):2474-8. doi: 10.1021/jm201289r. Epub 2012 Feb 15. J Med Chem. 2012. PMID: 22272748 Free PMC article.

7

Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.

Berndt N, Patel R, Yang H, Balasis ME, Sebti SM. Berndt N, et al. Among authors: sebti sm. Cell Cycle. 2013 Jul 1;12(13):2024-32. doi: 10.4161/cc.25043. Epub 2013 Jun 6. Cell Cycle. 2013. PMID: 23777806 Free PMC article.

8

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors.

Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang RHY, Ayaz M, Lawrence HR, Kennedy P, Sebti SM. Kazi A, et al. Among authors: sebti sm. Nat Commun. 2018 Dec 4;9(1):5154. doi: 10.1038/s41467-018-07644-6. Nat Commun. 2018. PMID: 30514931 Free PMC article.

9

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane.

Berndt N, Yang H, Trinczek B, Betzi S, Zhang Z, Wu B, Lawrence NJ, Pellecchia M, Schönbrunn E, Cheng JQ, Sebti SM. Berndt N, et al. Among authors: sebti sm. Cell Death Differ. 2010 Nov;17(11):1795-804. doi: 10.1038/cdd.2010.63. Epub 2010 May 21. Cell Death Differ. 2010. PMID: 20489726 Free PMC article.

10

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.

Yang H, Lawrence HR, Kazi A, Gevariya H, Patel R, Luo Y, Rix U, Schonbrunn E, Lawrence NJ, Sebti SM. Yang H, et al. Among authors: sebti sm. Oncotarget. 2014 May 30;5(10):2947-61. doi: 10.18632/oncotarget.1615. Oncotarget. 2014. PMID: 24930769 Free PMC article.

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