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The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.
Bacci S, Ludovico O, Prudente S, Zhang YY, Di Paola R, Mangiacotti D, Rauseo A, Nolan D, Duffy J, Fini G, Salvemini L, Amico C, Vigna C, Pellegrini F, Menzaghi C, Doria A, Trischitta V. Bacci S, et al. Diabetes. 2005 Oct;54(10):3021-5. doi: 10.2337/diabetes.54.10.3021. Diabetes. 2005. PMID: 16186408
The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy.
Menzaghi C, Paroni G, De Bonis C, Soccio T, Marucci A, Bacci S, Trischitta V. Menzaghi C, et al. Among authors: bacci s. J Am Soc Nephrol. 2006 Apr;17(4 Suppl 2):S115-9. doi: 10.1681/ASN.2005121340. J Am Soc Nephrol. 2006. PMID: 16565233
ENPP1 gene, insulin resistance and related clinical outcomes.
Bacci S, De Cosmo S, Prudente S, Trischitta V. Bacci S, et al. Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):403-9. doi: 10.1097/MCO.0b013e3281e386c9. Curr Opin Clin Nutr Metab Care. 2007. PMID: 17563456 Review.
199 results