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Page 1
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.
Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG. Staber PB, et al. Among authors: ebralidze ak. Blood. 2014 Oct 9;124(15):2391-9. doi: 10.1182/blood-2014-01-550855. Epub 2014 Sep 3. Blood. 2014. PMID: 25185713 Free PMC article.
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'Brien KB, Verhaak RG, Delwel R, Haase D, Trümper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG. Steidl U, et al. J Clin Invest. 2007 Sep;117(9):2611-20. doi: 10.1172/JCI30525. J Clin Invest. 2007. PMID: 17694175 Free PMC article.
The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.
Hoogenkamp M, Krysinska H, Ingram R, Huang G, Barlow R, Clarke D, Ebralidze A, Zhang P, Tagoh H, Cockerill PN, Tenen DG, Bonifer C. Hoogenkamp M, et al. Mol Cell Biol. 2007 Nov;27(21):7425-38. doi: 10.1128/MCB.00905-07. Epub 2007 Sep 4. Mol Cell Biol. 2007. PMID: 17785440 Free PMC article.
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.
Ebralidze AK, Guibal FC, Steidl U, Zhang P, Lee S, Bartholdy B, Jorda MA, Petkova V, Rosenbauer F, Huang G, Dayaram T, Klupp J, O'Brien KB, Will B, Hoogenkamp M, Borden KL, Bonifer C, Tenen DG. Ebralidze AK, et al. Genes Dev. 2008 Aug 1;22(15):2085-92. doi: 10.1101/gad.1654808. Genes Dev. 2008. PMID: 18676813 Free PMC article.
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez DA, Zhang J, Basseres DS, Wilson NK, Koschmieder S, Huang G, Zhang DE, Ebralidze AK, Bonifer C, Okuno Y, Gottgens B, Tenen DG. Levantini E, et al. Among authors: ebralidze ak. EMBO J. 2011 Aug 26;30(19):4059-70. doi: 10.1038/emboj.2011.285. EMBO J. 2011. PMID: 21873977 Free PMC article.
C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.
Alberich-Jordà M, Wouters B, Balastik M, Shapiro-Koss C, Zhang H, Di Ruscio A, Radomska HS, Ebralidze AK, Amabile G, Ye M, Zhang J, Lowers I, Avellino R, Melnick A, Figueroa ME, Valk PJ, Delwel R, Tenen DG. Alberich-Jordà M, et al. Among authors: ebralidze ak. J Clin Invest. 2012 Dec;122(12):4490-504. doi: 10.1172/JCI65102. Epub 2012 Nov 19. J Clin Invest. 2012. PMID: 23160200 Free PMC article.
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