Wang H - Search Results

1

Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.

Xue T, Ding S, Guo B, Zhou Y, Sun P, Wang H, Chu W, Gong G, Wang Y, Chen X, Yang Y. Xue T, et al. Among authors: wang h, wang y. J Med Chem. 2014 Sep 25;57(18):7770-91. doi: 10.1021/jm501045e. Epub 2014 Sep 15. J Med Chem. 2014. PMID: 25179681

2

Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening.

Cai H, Yan G, Zhang X, Gorbenko O, Wang H, Zhu W. Cai H, et al. Among authors: wang h. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. doi: 10.1016/j.bmcl.2010.04.095. Epub 2010 Apr 24. Bioorg Med Chem Lett. 2010. PMID: 20471252

3

Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis.

Wu J, Sun P, Zhang X, Liu H, Jiang H, Zhu W, Wang H. Wu J, et al. Among authors: wang h. J Cell Biochem. 2012 Apr;113(4):1152-8. doi: 10.1002/jcb.23450. J Cell Biochem. 2012. PMID: 22275065

4

Combining pharmacophore, docking and substructure search approaches to identify and optimize novel B-RafV600E inhibitors.

Xu Z, Yan G, Wang G, Li B, Zhu J, Sun P, Zhang X, Luo C, Wang H, Zhu W. Xu Z, et al. Among authors: wang h, wang g. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5428-37. doi: 10.1016/j.bmcl.2012.07.039. Epub 2012 Jul 17. Bioorg Med Chem Lett. 2012. PMID: 22858139

5

Diverse mechanisms of antidiabetic effects of the different procyanidin oligomer types of two different cinnamon species on db/db mice.

Chen L, Sun P, Wang T, Chen K, Jia Q, Wang H, Li Y. Chen L, et al. Among authors: wang h, wang t. J Agric Food Chem. 2012 Sep 12;60(36):9144-50. doi: 10.1021/jf3024535. Epub 2012 Aug 30. J Agric Food Chem. 2012. PMID: 22920511

6

DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice.

Sun P, Wang T, Zhou Y, Liu H, Jiang H, Zhu W, Wang H. Sun P, et al. Among authors: wang h, wang t. PLoS One. 2013 Jun 11;8(6):e66744. doi: 10.1371/journal.pone.0066744. Print 2013. PLoS One. 2013. PMID: 23776696 Free PMC article.

7

Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice.

Cai HY, Wang T, Zhao JC, Sun P, Yan GR, Ding HP, Li YX, Wang HY, Zhu WL, Chen KX. Cai HY, et al. Acta Pharmacol Sin. 2013 Nov;34(11):1397-402. doi: 10.1038/aps.2013.97. Epub 2013 Sep 30. Acta Pharmacol Sin. 2013. PMID: 24077632 Free PMC article.

8

Overman rearrangement and Pomeranz-Fritsch reaction for the synthesis of benzoazepinoisoquinolones to discover novel antitumor agents.

Li B, Wang G, Yang M, Xu Z, Zeng B, Wang H, Shen J, Chen K, Zhu W. Li B, et al. Among authors: wang h, wang g. Eur J Med Chem. 2013;70:677-84. doi: 10.1016/j.ejmech.2013.10.049. Epub 2013 Oct 25. Eur J Med Chem. 2013. PMID: 24215818

9

Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement.

Li B, Wang G, Xu Z, Zhang Y, Huang X, Zeng B, Chen K, Shi J, Wang H, Zhu W. Li B, et al. Among authors: wang h, wang g. Eur J Med Chem. 2014 Apr 22;77:204-10. doi: 10.1016/j.ejmech.2014.03.008. Epub 2014 Mar 6. Eur J Med Chem. 2014. PMID: 24637214

10

Brominated polyunsaturated lipids from the Chinese sponge Xestospongia testudinaria as a new class of pancreatic lipase inhibitors.

Liang LF, Wang T, Cai YS, He WF, Sun P, Li YF, Huang Q, Taglialatela-Scafati O, Wang HY, Guo YW. Liang LF, et al. Eur J Med Chem. 2014 May 22;79:290-7. doi: 10.1016/j.ejmech.2014.04.003. Epub 2014 Apr 8. Eur J Med Chem. 2014. PMID: 24747066

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