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Cardiac overexpression of constitutively active Galpha q causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice.
Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M. Matsushita N, et al. Among authors: kashihara t. PLoS One. 2014 Aug 29;9(8):e106354. doi: 10.1371/journal.pone.0106354. eCollection 2014. PLoS One. 2014. PMID: 25171374 Free PMC article.
Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.
Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M. Horiuchi-Hirose M, et al. Among authors: kashihara t. Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H978-88. doi: 10.1152/ajpheart.00508.2010. Epub 2010 Dec 30. Am J Physiol Heart Circ Physiol. 2011. PMID: 21193586 Free article.
Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure.
Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M. Kashihara T, et al. Am J Physiol Heart Circ Physiol. 2012 Apr 15;302(8):H1645-54. doi: 10.1152/ajpheart.00589.2011. Epub 2012 Feb 3. Am J Physiol Heart Circ Physiol. 2012. PMID: 22307674 Free article.
Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T. Yoshizawa T, et al. Among authors: kashihara t. Hypertension. 2013 Feb;61(2):341-51. doi: 10.1161/HYPERTENSIONAHA.111.00647. Epub 2013 Jan 7. Hypertension. 2013. PMID: 23297372
166 results