Smith TK - Search Results

1

Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.

Florence GJ, Fraser AL, Gould ER, King EF, Menzies SK, Morris JC, Tulloch LB, Smith TK. Florence GJ, et al. Among authors: smith tk. ChemMedChem. 2014 Nov;9(11):2548-56. doi: 10.1002/cmdc.201402272. Epub 2014 Aug 21. ChemMedChem. 2014. PMID: 25145275 Free PMC article.

2

First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness.

Smith TK, Young BL, Denton H, Hughes DL, Wagner GK. Smith TK, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1749-52. doi: 10.1016/j.bmcl.2009.01.083. Epub 2009 Jan 30. Bioorg Med Chem Lett. 2009. PMID: 19217283 Free PMC article.

3

Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases.

Tulloch LB, Martini VP, Iulek J, Huggan JK, Lee JH, Gibson CL, Smith TK, Suckling CJ, Hunter WN. Tulloch LB, et al. Among authors: smith tk. J Med Chem. 2010 Jan 14;53(1):221-9. doi: 10.1021/jm901059x. J Med Chem. 2010. PMID: 19916554 Free PMC article.

4

GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei.

Denton H, Fyffe S, Smith TK. Denton H, et al. Among authors: smith tk. Biochem J. 2010 Jan 15;425(3):603-14. doi: 10.1042/BJ20090896. Biochem J. 2010. PMID: 19919534

5

Lipid metabolism in Trypanosoma brucei.

Smith TK, Bütikofer P. Smith TK, et al. Mol Biochem Parasitol. 2010 Aug;172(2):66-79. doi: 10.1016/j.molbiopara.2010.04.001. Epub 2010 Apr 9. Mol Biochem Parasitol. 2010. PMID: 20382188 Free PMC article. Review.

6

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei.

Young SA, Smith TK. Young SA, et al. Among authors: smith tk. Mol Microbiol. 2010 Jun;76(6):1461-82. doi: 10.1111/j.1365-2958.2010.07151.x. Epub 2010 Apr 1. Mol Microbiol. 2010. PMID: 20398210 Free PMC article.

7

Lipidomic analysis of bloodstream and procyclic form Trypanosoma brucei.

Richmond GS, Gibellini F, Young SA, Major L, Denton H, Lilley A, Smith TK. Richmond GS, et al. Among authors: smith tk. Parasitology. 2010 Aug;137(9):1357-92. doi: 10.1017/S0031182010000715. Parasitology. 2010. PMID: 20602846 Free PMC article. Review.

8

Synthesis and stereochemical assignment of (+)-chamuvarinin.

Florence GJ, Morris JC, Murray RG, Osler JD, Reddy VR, Smith TK. Florence GJ, et al. Among authors: smith tk. Org Lett. 2011 Feb 4;13(3):514-7. doi: 10.1021/ol1028699. Epub 2010 Dec 21. Org Lett. 2011. PMID: 21174397 Free PMC article.

9

Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.

Tamborini L, Pinto A, Smith TK, Major LL, Iannuzzi MC, Cosconati S, Marinelli L, Novellino E, Lo Presti L, Wong PE, Barrett MP, De Micheli C, Conti P. Tamborini L, et al. Among authors: smith tk. ChemMedChem. 2012 Sep;7(9):1623-34. doi: 10.1002/cmdc.201200304. Epub 2012 Aug 2. ChemMedChem. 2012. PMID: 22865834 Free PMC article.

10

A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.

Zhou L, Stewart G, Rideau E, Westwood NJ, Smith TK. Zhou L, et al. Among authors: smith tk. J Med Chem. 2013 Feb 14;56(3):796-806. doi: 10.1021/jm301215e. Epub 2013 Jan 15. J Med Chem. 2013. PMID: 23281892 Free PMC article.

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