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Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
Deng H, O'Keefe H, Davie CP, Lind KE, Acharya RA, Franklin GJ, Larkin J, Matico R, Neeb M, Thompson MM, Lohr T, Gross JW, Centrella PA, O'Donovan GK, Bedard KL, van Vloten K, Mataruse S, Skinner SR, Belyanskaya SL, Carpenter TY, Shearer TW, Clark MA, Cuozzo JW, Arico-Muendel CC, Morgan BA. Deng H, et al. Among authors: larkin j. J Med Chem. 2012 Aug 23;55(16):7061-79. doi: 10.1021/jm300449x. Epub 2012 Aug 14. J Med Chem. 2012. PMID: 22891645
Current and emerging treatment options for BRAFV600-mutant melanoma.
Javaid A, Peres T, Pozas J, Thomas J, Larkin J. Javaid A, et al. Among authors: larkin j. Expert Rev Anticancer Ther. 2025 Jan;25(1):55-69. doi: 10.1080/14737140.2025.2451722. Epub 2025 Jan 16. Expert Rev Anticancer Ther. 2025. PMID: 39784319 Review.
Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal.
Fernández-Sanromán Á, Fendler A, Tan BJY, Cattin AL, Spencer C, Thompson R, Au L, Lobon I, Pallikonda HA, Martin A, Byrne F, Franz A, Mikolajczak A, Rahman H, Tippu Z, Shepherd STC, Feng H, Deng D, Rowan A, Pickering L, Furness AJS, Young K, Nicol D, Rudman SM, O'Brien T, Edmonds K, Chandra A, Hazell S, Litchfield K, Kassiotis G, Larkin J, Turajlic S. Fernández-Sanromán Á, et al. Among authors: larkin j. Cancer Discov. 2025 Jan 9:OF1-OF23. doi: 10.1158/2159-8290.CD-24-0499. Online ahead of print. Cancer Discov. 2025. PMID: 39784160
Tracking non-genetic evolution from primary to metastatic ccRCC: TRACERx Renal.
Fernández-Sanromán Á, Fendler A, Tan BJY, Cattin AL, Spencer C, Thompson R, Au L, Lobon I, Pallikonda HA, Martin A, Byrne F, Franz A, Mikolajczak A, Rahman H, Tippu Z, Shepherd STC, Feng H, Deng D, Rowan A, Pickering L, Furness AJS, Young K, Nicol D, Rudman SM, O'Brien T, Edmonds K, Chandra A, Hazell S, Litchfield K, Kassiotis G, Larkin J, Turajlic S. Fernández-Sanromán Á, et al. Among authors: larkin j. Cancer Discov. 2025 Jan 8. doi: 10.1158/2159-8290.CD-24-0499. Online ahead of print. Cancer Discov. 2025. PMID: 39774619
1,288 results