Hirst WD - Search Results

1

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.

Galatsis P, Henderson JL, Kormos BL, Han S, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD. Galatsis P, et al. Among authors: hirst wd. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4132-40. doi: 10.1016/j.bmcl.2014.07.052. Epub 2014 Jul 30. Bioorg Med Chem Lett. 2014. PMID: 25113930

2

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

Anand VS, Reichling LJ, Lipinski K, Stochaj W, Duan W, Kelleher K, Pungaliya P, Brown EL, Reinhart PH, Somberg R, Hirst WD, Riddle SM, Braithwaite SP. Anand VS, et al. Among authors: hirst wd. FEBS J. 2009 Jan;276(2):466-78. doi: 10.1111/j.1742-4658.2008.06789.x. FEBS J. 2009. PMID: 19076219 Free article.

3

Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2.

Atkinson PJ, Dellovade T, Albers D, Von Schack D, Saraf K, Needle E, Reinhart PH, Hirst WD. Atkinson PJ, et al. Among authors: hirst wd. J Neurochem. 2009 Mar;108(6):1539-49. doi: 10.1111/j.1471-4159.2009.05900.x. Epub 2009 Jan 22. J Neurochem. 2009. PMID: 19183261 Free article.

4

Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors.

Donnell AF, Dollings PJ, Butera JA, Dietrich AJ, Lipinski KK, Ghavami A, Hirst WD. Donnell AF, et al. Among authors: hirst wd. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2163-7. doi: 10.1016/j.bmcl.2010.02.044. Epub 2010 Feb 13. Bioorg Med Chem Lett. 2010. PMID: 20202838

5

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.

Pungaliya PP, Bai Y, Lipinski K, Anand VS, Sen S, Brown EL, Bates B, Reinhart PH, West AB, Hirst WD, Braithwaite SP. Pungaliya PP, et al. Among authors: hirst wd. PLoS One. 2010 Oct 27;5(10):e13672. doi: 10.1371/journal.pone.0013672. PLoS One. 2010. PMID: 21060682 Free PMC article.

6

Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.

Luerman GC, Nguyen C, Samaroo H, Loos P, Xi H, Hurtado-Lorenzo A, Needle E, Stephen Noell G, Galatsis P, Dunlop J, Geoghegan KF, Hirst WD. Luerman GC, et al. Among authors: hirst wd. J Neurochem. 2014 Feb;128(4):561-76. doi: 10.1111/jnc.12483. Epub 2013 Nov 11. J Neurochem. 2014. PMID: 24117733 Free article.

7

Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons.

Li L, Nadanaciva S, Berger Z, Shen W, Paumier K, Schwartz J, Mou K, Loos P, Milici AJ, Dunlop J, Hirst WD. Li L, et al. Among authors: hirst wd. PLoS One. 2013 Dec 31;8(12):e85815. doi: 10.1371/journal.pone.0085815. eCollection 2013. PLoS One. 2013. PMID: 24392030 Free PMC article.

8

Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons.

Shen W, Henry AG, Paumier KL, Li L, Mou K, Dunlop J, Berger Z, Hirst WD. Shen W, et al. Among authors: hirst wd. J Neurochem. 2014 Jun;129(5):884-94. doi: 10.1111/jnc.12672. Epub 2014 Mar 3. J Neurochem. 2014. PMID: 24494600 Free article.

9

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.

Henderson JL, Kormos BL, Hayward MM, Coffman KJ, Jasti J, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD, Galatsis P. Henderson JL, et al. Among authors: hirst wd. J Med Chem. 2015 Jan 8;58(1):419-32. doi: 10.1021/jm5014055. Epub 2014 Nov 17. J Med Chem. 2015. PMID: 25353650

10

Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.

Berger Z, Perkins S, Ambroise C, Oborski C, Calabrese M, Noell S, Riddell D, Hirst WD. Berger Z, et al. Among authors: hirst wd. PLoS One. 2015 Mar 12;10(3):e0119141. doi: 10.1371/journal.pone.0119141. eCollection 2015. PLoS One. 2015. PMID: 25763858 Free PMC article.

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