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Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death.
Yoshida T, Friehs I, Mummidi S, del Nido PJ, Addulnour-Nakhoul S, Delafontaine P, Valente AJ, Chandrasekar B. Yoshida T, et al. Among authors: valente aj. J Mol Cell Cardiol. 2014 Oct;75:141-51. doi: 10.1016/j.yjmcc.2014.07.007. Epub 2014 Aug 7. J Mol Cell Cardiol. 2014. PMID: 25108227 Free PMC article.
EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling.
Venkatesan B, Valente AJ, Prabhu SD, Shanmugam P, Delafontaine P, Chandrasekar B. Venkatesan B, et al. Among authors: valente aj. J Mol Cell Cardiol. 2010 Oct;49(4):655-63. doi: 10.1016/j.yjmcc.2010.05.007. Epub 2010 Jun 9. J Mol Cell Cardiol. 2010. PMID: 20538003 Free PMC article.
β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo.
Murray DR, Mummidi S, Valente AJ, Yoshida T, Somanna NK, Delafontaine P, Dinarello CA, Chandrasekar B. Murray DR, et al. Among authors: valente aj. J Mol Cell Cardiol. 2012 Jan;52(1):206-18. doi: 10.1016/j.yjmcc.2011.09.022. Epub 2011 Oct 8. J Mol Cell Cardiol. 2012. PMID: 22004899 Free PMC article.
234 results