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Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death.
Yoshida T, Friehs I, Mummidi S, del Nido PJ, Addulnour-Nakhoul S, Delafontaine P, Valente AJ, Chandrasekar B. Yoshida T, et al. Among authors: delafontaine p. J Mol Cell Cardiol. 2014 Oct;75:141-51. doi: 10.1016/j.yjmcc.2014.07.007. Epub 2014 Aug 7. J Mol Cell Cardiol. 2014. PMID: 25108227 Free PMC article.
EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling.
Venkatesan B, Valente AJ, Prabhu SD, Shanmugam P, Delafontaine P, Chandrasekar B. Venkatesan B, et al. Among authors: delafontaine p. J Mol Cell Cardiol. 2010 Oct;49(4):655-63. doi: 10.1016/j.yjmcc.2010.05.007. Epub 2010 Jun 9. J Mol Cell Cardiol. 2010. PMID: 20538003 Free PMC article.
Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation.
Reddy VS, Prabhu SD, Mummidi S, Valente AJ, Venkatesan B, Shanmugam P, Delafontaine P, Chandrasekar B. Reddy VS, et al. Among authors: delafontaine p. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1242-54. doi: 10.1152/ajpheart.00451.2010. Epub 2010 Aug 6. Am J Physiol Heart Circ Physiol. 2010. PMID: 20693392 Free PMC article.
Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.
Semprun-Prieto LC, Sukhanov S, Yoshida T, Rezk BM, Gonzalez-Villalobos RA, Vaughn C, Michael Tabony A, Delafontaine P. Semprun-Prieto LC, et al. Among authors: delafontaine p. Biochem Biophys Res Commun. 2011 Jun 3;409(2):217-21. doi: 10.1016/j.bbrc.2011.04.122. Epub 2011 May 6. Biochem Biophys Res Commun. 2011. PMID: 21570954 Free PMC article.
Angiotensin II, oxidative stress and skeletal muscle wasting.
Sukhanov S, Semprun-Prieto L, Yoshida T, Michael Tabony A, Higashi Y, Galvez S, Delafontaine P. Sukhanov S, et al. Among authors: delafontaine p. Am J Med Sci. 2011 Aug;342(2):143-7. doi: 10.1097/MAJ.0b013e318222e620. Am J Med Sci. 2011. PMID: 21747283 Free PMC article. Review.
198 results