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N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.
Désiré J, Mondon M, Fontelle N, Nakagawa S, Hirokami Y, Adachi I, Iwaki R, Fleet GW, Alonzi DS, Twigg G, Butters TD, Bertrand J, Cendret V, Becq F, Norez C, Marrot J, Kato A, Blériot Y. Désiré J, et al. Among authors: bertrand j. Org Biomol Chem. 2014 Nov 28;12(44):8977-96. doi: 10.1039/c4ob00325j. Org Biomol Chem. 2014. PMID: 25277226
Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.
Cendret V, Legigan T, Mingot A, Thibaudeau S, Adachi I, Forcella M, Parenti P, Bertrand J, Becq F, Norez C, Désiré J, Kato A, Blériot Y. Cendret V, et al. Among authors: bertrand j. Org Biomol Chem. 2015 Nov 21;13(43):10734-44. doi: 10.1039/c5ob01526j. Org Biomol Chem. 2015. PMID: 26356422 Free article.
Human Oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome.
Garrigue A, Kermasson L, Susini S, Fert I, Mahony CB, Sadek H, Luce S, Chouteau M, Cavazzana M, Six E, Le Bousse-Kerdilès MC, Anginot A, Souraud JB, Cormier-Daire V, Willems M, Sirvent A, Russello J, Callebaut I, André I, Bertrand JY, Lagresle-Peyrou C, Revy P. Garrigue A, et al. Among authors: bertrand jy. J Clin Invest. 2025 Jan 23:e180981. doi: 10.1172/JCI180981. Online ahead of print. J Clin Invest. 2025. PMID: 39847438
TRPC1 links calcium signaling to cellular senescence in the protection against post-traumatic osteoarthritis.
Sambale M, Lively S, Espin-Garcia O, Potla P, Pastrello C, Bödecker S, Wessendorf L, Kleimann S, Paruzel P, Asgarian R, Tosun A, Intemann J, Bertrand J, Dell'Accio F, Kapoor M, Pap T, Sherwood J. Sambale M, et al. Among authors: bertrand j. JCI Insight. 2024 Dec 24:e182103. doi: 10.1172/jci.insight.182103. Online ahead of print. JCI Insight. 2024. PMID: 39718827 Free article.
1,760 results