Sabatini DM - Search Results

1

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.

Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM. Lamming DW, et al. Among authors: sabatini dm. Aging Cell. 2014 Oct;13(5):911-7. doi: 10.1111/acel.12256. Epub 2014 Jul 25. Aging Cell. 2014. PMID: 25059582 Free PMC article.

2

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5. Cell. 2002. PMID: 12150925 Free article.

3

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Mol Cell. 2003 Apr;11(4):895-904. doi: 10.1016/s1097-2765(03)00114-x. Mol Cell. 2003. PMID: 12718876 Free article.

4

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Sarbassov DD, et al. Among authors: sabatini dm. Curr Biol. 2004 Jul 27;14(14):1296-302. doi: 10.1016/j.cub.2004.06.054. Curr Biol. 2004. PMID: 15268862 Free article.

5

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Sarbassov DD, et al. Among authors: sabatini dm. Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148. Science. 2005. PMID: 15718470

6

Growing roles for the mTOR pathway.

Sarbassov DD, Ali SM, Sabatini DM. Sarbassov DD, et al. Among authors: sabatini dm. Curr Opin Cell Biol. 2005 Dec;17(6):596-603. doi: 10.1016/j.ceb.2005.09.009. Epub 2005 Oct 13. Curr Opin Cell Biol. 2005. PMID: 16226444 Review.

7

eIF3: a connecTOR of S6K1 to the translation preinitiation complex.

Peterson TR, Sabatini DM. Peterson TR, et al. Among authors: sabatini dm. Mol Cell. 2005 Dec 9;20(5):655-7. doi: 10.1016/j.molcel.2005.11.016. Mol Cell. 2005. PMID: 16337588 Free article. Review.

8

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.

Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. Sarbassov DD, et al. Among authors: sabatini dm. Mol Cell. 2006 Apr 21;22(2):159-68. doi: 10.1016/j.molcel.2006.03.029. Epub 2006 Apr 6. Mol Cell. 2006. PMID: 16603397 Free article.

9

mTOR and cancer: insights into a complex relationship.

Sabatini DM. Sabatini DM. Nat Rev Cancer. 2006 Sep;6(9):729-34. doi: 10.1038/nrc1974. Epub 2006 Aug 17. Nat Rev Cancer. 2006. PMID: 16915295 Review.

10

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. Guertin DA, et al. Among authors: sabatini dm. Dev Cell. 2006 Dec;11(6):859-71. doi: 10.1016/j.devcel.2006.10.007. Dev Cell. 2006. PMID: 17141160 Free article.

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