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Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide.
Ishiguro N, Maeda K, Saito A, Kishimoto W, Matsushima S, Ebner T, Roth W, Igarashi T, Sugiyama Y. Ishiguro N, et al. Among authors: kishimoto w. Drug Metab Dispos. 2008 Apr;36(4):796-805. doi: 10.1124/dmd.107.018903. Epub 2008 Jan 7. Drug Metab Dispos. 2008. PMID: 18180273
Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.
Ohtsuki S, Schaefer O, Kawakami H, Inoue T, Liehner S, Saito A, Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, Ebner T, Terasaki T. Ohtsuki S, et al. Among authors: kishimoto w. Drug Metab Dispos. 2012 Jan;40(1):83-92. doi: 10.1124/dmd.111.042259. Epub 2011 Oct 12. Drug Metab Dispos. 2012. PMID: 21994437
Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species.
Taub ME, Ludwig-Schwellinger E, Ishiguro N, Kishimoto W, Yu H, Wagner K, Tweedie D. Taub ME, et al. Among authors: kishimoto w. Chem Res Toxicol. 2015 Jan 20;28(1):103-15. doi: 10.1021/tx500380t. Epub 2015 Jan 5. Chem Res Toxicol. 2015. PMID: 25489797
74 results