Brennan FM - Search Results

1

A novel upstream enhancer of FOXP3, sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells.

Kennedy A, Schmidt EM, Cribbs AP, Penn H, Amjadi P, Syed K, Read JE, Green P, Gregory B, Brennan FM. Kennedy A, et al. Among authors: brennan fm. Eur J Immunol. 2014 Oct;44(10):2968-78. doi: 10.1002/eji.201444453. Epub 2014 Aug 18. Eur J Immunol. 2014. PMID: 25042153 Free article.

2

Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis.

Cribbs AP, Kennedy A, Penn H, Amjadi P, Green P, Read JE, Brennan F, Gregory B, Williams RO. Cribbs AP, et al. Arthritis Rheumatol. 2015 May;67(5):1182-92. doi: 10.1002/art.39031. Arthritis Rheumatol. 2015. PMID: 25604080

3

Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

Beavis PA, Gregory B, Green P, Cribbs AP, Kennedy A, Amjadi P, Palfreeman AC, Feldmann M, Brennan FM. Beavis PA, et al. Among authors: brennan fm. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16717-22. doi: 10.1073/pnas.1112722108. Epub 2011 Sep 16. Proc Natl Acad Sci U S A. 2011. PMID: 21926327 Free PMC article.

4

Treg cell function in rheumatoid arthritis is compromised by ctla-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway.

Cribbs AP, Kennedy A, Penn H, Read JE, Amjadi P, Green P, Syed K, Manka SW, Brennan FM, Gregory B, Williams RO. Cribbs AP, et al. Among authors: brennan fm. Arthritis Rheumatol. 2014 Sep;66(9):2344-54. doi: 10.1002/art.38715. Arthritis Rheumatol. 2014. PMID: 24891289

5

Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model.

Sacre S, Lo A, Gregory B, Stephens M, Chamberlain G, Stott P, Brennan F. Sacre S, et al. Eur J Immunol. 2016 Mar;46(3):772-81. doi: 10.1002/eji.201546123. Epub 2015 Dec 16. Eur J Immunol. 2016. PMID: 26593270 Free article.

6

Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.

Brennan FM, Smith NM, Owen S, Li C, Amjadi P, Green P, Andersson A, Palfreeman AC, Hillyer P, Foey A, Beech JT, Feldmann M. Brennan FM, et al. Arthritis Res Ther. 2008;10(2):R36. doi: 10.1186/ar2390. Epub 2008 Mar 19. Arthritis Res Ther. 2008. PMID: 18353171 Free PMC article.

7

Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.

Brennan FM, Green P, Amjadi P, Robertshaw HJ, Alvarez-Iglesias M, Takata M. Brennan FM, et al. Eur J Immunol. 2008 Apr;38(4):1106-17. doi: 10.1002/eji.200737821. Eur J Immunol. 2008. PMID: 18383040 Free article.

8

Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor.

Li C, Beavis P, Palfreeman AC, Amjadi P, Kennedy A, Brennan FM. Li C, et al. Among authors: brennan fm. Immunology. 2011 Jan;132(1):104-10. doi: 10.1111/j.1365-2567.2010.03345.x. Epub 2010 Sep 28. Immunology. 2011. PMID: 20875074 Free PMC article.

9

Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures.

Schmidt EM, Davies M, Mistry P, Green P, Giddins G, Feldmann M, Stoop AA, Brennan FM. Schmidt EM, et al. Among authors: brennan fm. Arthritis Rheum. 2013 Sep;65(9):2262-73. doi: 10.1002/art.38055. Arthritis Rheum. 2013. PMID: 23784528 Free article.

10

Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells.

Cribbs AP, Kennedy A, Gregory B, Brennan FM. Cribbs AP, et al. Among authors: brennan fm. BMC Biotechnol. 2013 Nov 12;13:98. doi: 10.1186/1472-6750-13-98. BMC Biotechnol. 2013. PMID: 24215295 Free PMC article.

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