Conn PJ - Search Results

1

Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.

Pollard M, Bartolome JM, Conn PJ, Steckler T, Shaban H. Pollard M, et al. Among authors: conn pj. J Psychopharmacol. 2014 Oct;28(10):935-46. doi: 10.1177/0269881114542856. Epub 2014 Jul 16. J Psychopharmacol. 2014. PMID: 25031220 Free PMC article.

2

The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.

Campbell UC, Lalwani K, Hernandez L, Kinney GG, Conn PJ, Bristow LJ. Campbell UC, et al. Among authors: conn pj. Psychopharmacology (Berl). 2004 Sep;175(3):310-8. doi: 10.1007/s00213-004-1827-5. Psychopharmacology (Berl). 2004. PMID: 15024550

3

Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes.

Zhang Y, Rodriguez AL, Conn PJ. Zhang Y, et al. Among authors: conn pj. J Pharmacol Exp Ther. 2005 Dec;315(3):1212-9. doi: 10.1124/jpet.105.090308. Epub 2005 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 16135701

4

Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.

Galici R, Jones CK, Hemstapat K, Nong Y, Echemendia NG, Williams LC, de Paulis T, Conn PJ. Galici R, et al. Among authors: conn pj. J Pharmacol Exp Ther. 2006 Jul;318(1):173-85. doi: 10.1124/jpet.106.102046. Epub 2006 Apr 11. J Pharmacol Exp Ther. 2006. PMID: 16608916

5

A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.

Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. Hemstapat K, et al. Among authors: conn pj. Mol Pharmacol. 2006 Aug;70(2):616-26. doi: 10.1124/mol.105.021857. Epub 2006 Apr 27. Mol Pharmacol. 2006. PMID: 16645124

6

Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.

de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ. de Paulis T, et al. Among authors: conn pj. J Med Chem. 2006 Jun 1;49(11):3332-44. doi: 10.1021/jm051252j. J Med Chem. 2006. PMID: 16722652

7

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ. Chen Y, et al. Among authors: conn pj. Mol Pharmacol. 2007 May;71(5):1389-98. doi: 10.1124/mol.106.032425. Epub 2007 Feb 15. Mol Pharmacol. 2007. PMID: 17303702

8

A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.

Benneyworth MA, Xiang Z, Smith RL, Garcia EE, Conn PJ, Sanders-Bush E. Benneyworth MA, et al. Among authors: conn pj. Mol Pharmacol. 2007 Aug;72(2):477-84. doi: 10.1124/mol.107.035170. Epub 2007 May 25. Mol Pharmacol. 2007. PMID: 17526600

9

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.

Chen Y, Goudet C, Pin JP, Conn PJ. Chen Y, et al. Among authors: conn pj. Mol Pharmacol. 2008 Mar;73(3):909-18. doi: 10.1124/mol.107.040097. Epub 2007 Dec 4. Mol Pharmacol. 2008. PMID: 18056795

10

Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.

Sharma S, Rodriguez AL, Conn PJ, Lindsley CW. Sharma S, et al. Among authors: conn pj. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. doi: 10.1016/j.bmcl.2008.05.091. Epub 2008 May 29. Bioorg Med Chem Lett. 2008. PMID: 18550372 Free PMC article.

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