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105 results

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Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.
Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA. Stothert AR, et al. Among authors: lieberman rl. Hum Mol Genet. 2014 Dec 15;23(24):6470-80. doi: 10.1093/hmg/ddu367. Epub 2014 Jul 15. Hum Mol Genet. 2014. PMID: 25027323 Free PMC article.
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
Suntharalingam A, Abisambra JF, O'Leary JC 3rd, Koren J 3rd, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Suntharalingam A, et al. Among authors: lieberman rl. J Biol Chem. 2012 Nov 23;287(48):40661-9. doi: 10.1074/jbc.M112.384800. Epub 2012 Oct 3. J Biol Chem. 2012. PMID: 23035116 Free PMC article.
Ligands for glaucoma-associated myocilin discovered by a generic binding assay.
Orwig SD, Chi PV, Du Y, Hill SE, Cavitt MA, Suntharalingam A, Turnage KC, Dickey CA, France S, Fu H, Lieberman RL. Orwig SD, et al. Among authors: lieberman rl. ACS Chem Biol. 2014 Feb 21;9(2):517-25. doi: 10.1021/cb4007776. Epub 2013 Dec 9. ACS Chem Biol. 2014. PMID: 24279319 Free PMC article.
Structural basis for misfolding in myocilin-associated glaucoma.
Donegan RK, Hill SE, Freeman DM, Nguyen E, Orwig SD, Turnage KC, Lieberman RL. Donegan RK, et al. Among authors: lieberman rl. Hum Mol Genet. 2015 Apr 15;24(8):2111-24. doi: 10.1093/hmg/ddu730. Epub 2014 Dec 18. Hum Mol Genet. 2015. PMID: 25524706 Free PMC article.
105 results