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Page 1
Development of a Grp94 inhibitor.
Duerfeldt AS, Peterson LB, Maynard JC, Ng CL, Eletto D, Ostrovsky O, Shinogle HE, Moore DS, Argon Y, Nicchitta CV, Blagg BS. Duerfeldt AS, et al. Among authors: blagg bs. J Am Chem Soc. 2012 Jun 13;134(23):9796-804. doi: 10.1021/ja303477g. Epub 2012 May 29. J Am Chem Soc. 2012. PMID: 22642269 Free PMC article.
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
Suntharalingam A, Abisambra JF, O'Leary JC 3rd, Koren J 3rd, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Suntharalingam A, et al. Among authors: blagg bs. J Biol Chem. 2012 Nov 23;287(48):40661-9. doi: 10.1074/jbc.M112.384800. Epub 2012 Oct 3. J Biol Chem. 2012. PMID: 23035116 Free PMC article.
Development of radamide analogs as Grp94 inhibitors.
Muth A, Crowley V, Khandelwal A, Mishra S, Zhao J, Hall J, Blagg BS. Muth A, et al. Among authors: blagg bs. Bioorg Med Chem. 2014 Aug 1;22(15):4083-98. doi: 10.1016/j.bmc.2014.05.075. Epub 2014 Jun 12. Bioorg Med Chem. 2014. PMID: 25027801 Free PMC article.
Hsp90 activator Aha1 drives production of pathological tau aggregates.
Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J 3rd, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA. Shelton LB, et al. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9707-9712. doi: 10.1073/pnas.1707039114. Epub 2017 Aug 21. Proc Natl Acad Sci U S A. 2017. PMID: 28827321 Free PMC article.
Resorcinol-Based Grp94-Selective Inhibitors.
Khandelwal A, Crowley VM, Blagg BSJ. Khandelwal A, et al. ACS Med Chem Lett. 2017 Sep 1;8(10):1013-1018. doi: 10.1021/acsmedchemlett.7b00193. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057043 Free PMC article.
213 results