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Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.
Darrah PA, Bolton DL, Lackner AA, Kaushal D, Aye PP, Mehra S, Blanchard JL, Didier PJ, Roy CJ, Rao SS, Hokey DA, Scanga CA, Sizemore DR, Sadoff JC, Roederer M, Seder RA. Darrah PA, et al. Among authors: scanga ca. J Immunol. 2014 Aug 15;193(4):1799-811. doi: 10.4049/jimmunol.1400676. Epub 2014 Jul 14. J Immunol. 2014. PMID: 25024382 Free PMC article.
rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector.
Magalhaes I, Sizemore DR, Ahmed RK, Mueller S, Wehlin L, Scanga C, Weichold F, Schirru G, Pau MG, Goudsmit J, Kühlmann-Berenzon S, Spångberg M, Andersson J, Gaines H, Thorstensson R, Skeiky YA, Sadoff J, Maeurer M. Magalhaes I, et al. PLoS One. 2008;3(11):e3790. doi: 10.1371/journal.pone.0003790. Epub 2008 Nov 21. PLoS One. 2008. PMID: 19023426 Free PMC article.
Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis.
Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC. Sun R, et al. Vaccine. 2009 Jul 16;27(33):4412-23. doi: 10.1016/j.vaccine.2009.05.048. Epub 2009 Jun 2. Vaccine. 2009. PMID: 19500523
Prime-boost vaccination with rBCG/rAd35 enhances CD8⁺ cytolytic T-cell responses in lesions from Mycobacterium tuberculosis-infected primates.
Rahman S, Magalhaes I, Rahman J, Ahmed RK, Sizemore DR, Scanga CA, Weichold F, Verreck F, Kondova I, Sadoff J, Thorstensson R, Spångberg M, Svensson M, Andersson J, Maeurer M, Brighenti S. Rahman S, et al. Among authors: scanga ca. Mol Med. 2012 May 9;18(1):647-58. doi: 10.2119/molmed.2011.00222. Mol Med. 2012. PMID: 22396020 Free PMC article.
A tuberculosis ontology for host systems biology.
Levine DM, Dutta NK, Eckels J, Scanga C, Stein C, Mehra S, Kaushal D, Karakousis PC, Salamon H. Levine DM, et al. Tuberculosis (Edinb). 2015 Sep;95(5):570-4. doi: 10.1016/j.tube.2015.05.012. Epub 2015 Jun 30. Tuberculosis (Edinb). 2015. PMID: 26190839 Free PMC article.
83 results