Lea WA - Search Results

1

Biochemical assays for the discovery of TDP1 inhibitors.

Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y. Marchand C, et al. Among authors: lea wa. Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14. Mol Cancer Ther. 2014. PMID: 25024006 Free PMC article.

2

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Marchand C, et al. Among authors: lea wa. Mol Cancer Ther. 2009 Jan;8(1):240-8. doi: 10.1158/1535-7163.MCT-08-0878. Mol Cancer Ther. 2009. PMID: 19139134 Free PMC article.

3

Fluorescence polarization assays in small molecule screening.

Lea WA, Simeonov A. Lea WA, et al. Expert Opin Drug Discov. 2011 Jan;6(1):17-32. doi: 10.1517/17460441.2011.537322. Expert Opin Drug Discov. 2011. PMID: 22328899 Free PMC article.

4

Discovery of a novel general anesthetic chemotype using high-throughput screening.

McKinstry-Wu AR, Bu W, Rai G, Lea WA, Weiser BP, Liang DF, Simeonov A, Jadhav A, Maloney DJ, Eckenhoff RG. McKinstry-Wu AR, et al. Among authors: lea wa. Anesthesiology. 2015 Feb;122(2):325-33. doi: 10.1097/ALN.0000000000000505. Anesthesiology. 2015. PMID: 25603205 Free PMC article.

5

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.

Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. Lea WA, et al. Assay Drug Dev Technol. 2008 Aug;6(4):551-5. doi: 10.1089/adt.2008.149. Assay Drug Dev Technol. 2008. PMID: 18665782 Free PMC article.

6

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Auld DS, et al. Among authors: lea wa. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194791 Free PMC article.

7

Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase.

Lea WA, Simeonov A. Lea WA, et al. PLoS One. 2012;7(4):e36219. doi: 10.1371/journal.pone.0036219. Epub 2012 Apr 30. PLoS One. 2012. PMID: 22558390 Free PMC article.

8

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.

Martinez NJ, Rai G, Yasgar A, Lea WA, Sun H, Wang Y, Luci DK, Yang SM, Nishihara K, Takeda S, Sagor M, Earnshaw I, Okada T, Mori K, Wilson K, Riggins GJ, Xia M, Grimaldi M, Jadhav A, Maloney DJ, Simeonov A. Martinez NJ, et al. Among authors: lea wa. PLoS One. 2016 Aug 29;11(8):e0161486. doi: 10.1371/journal.pone.0161486. eCollection 2016. PLoS One. 2016. PMID: 27570969 Free PMC article.

9

A high-throughput approach for identification of novel general anesthetics.

Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. Lea WA, et al. PLoS One. 2009 Sep 24;4(9):e7150. doi: 10.1371/journal.pone.0007150. PLoS One. 2009. PMID: 19777064 Free PMC article.

10

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

Thorne N, Shen M, Lea WA, Simeonov A, Lovell S, Auld DS, Inglese J. Thorne N, et al. Among authors: lea wa. Chem Biol. 2012 Aug 24;19(8):1060-72. doi: 10.1016/j.chembiol.2012.07.015. Chem Biol. 2012. PMID: 22921073 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

48 results

Search Page

Filters