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The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury.
Lewarchik CM, Orabi AI, Jin S, Wang D, Muili KA, Shah AU, Eisses JF, Malik A, Bottino R, Jayaraman T, Husain SZ. Lewarchik CM, et al. Among authors: bottino r. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G574-81. doi: 10.1152/ajpgi.00143.2014. Epub 2014 Jul 10. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 25012845 Free PMC article.
Single-cell analyses of human pancreas: characteristics of two populations of acinar cells in chronic pancreatitis.
Blobner BM, Saloman JL, Shelton Ohlsen CA, Brand R, Lafyatis R, Bottino R, Wijkstrom M, Zureikat AH, Lee KK, Singhi AD, Ross MA, Stolz D, Whitcomb DC. Blobner BM, et al. Among authors: bottino r. Am J Physiol Gastrointest Liver Physiol. 2021 Nov 1;321(5):G449-G460. doi: 10.1152/ajpgi.00482.2020. Epub 2021 Sep 15. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 34523348 Free PMC article.
Decreased pancreatic acinar cell number in type 1 diabetes.
Wright JJ, Saunders DC, Dai C, Poffenberger G, Cairns B, Serreze DV, Harlan DM, Bottino R, Brissova M, Powers AC. Wright JJ, et al. Among authors: bottino r. Diabetologia. 2020 Jul;63(7):1418-1423. doi: 10.1007/s00125-020-05155-y. Epub 2020 May 9. Diabetologia. 2020. PMID: 32388592 Free PMC article.
Dapagliflozin Does Not Directly Affect Human α or β Cells.
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC. Dai C, et al. Among authors: bottino r. Endocrinology. 2020 Aug 1;161(8):bqaa080. doi: 10.1210/endocr/bqaa080. Endocrinology. 2020. PMID: 32428240 Free PMC article.
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells.
Coate KC, Cha J, Shrestha S, Wang W, Gonçalves LM, Almaça J, Kapp ME, Fasolino M, Morgan A, Dai C, Saunders DC, Bottino R, Aramandla R, Jenkins R, Stein R, Kaestner KH, Vahedi G; HPAP Consortium; Brissova M, Powers AC. Coate KC, et al. Among authors: bottino r. Cell Metab. 2020 Dec 1;32(6):1028-1040.e4. doi: 10.1016/j.cmet.2020.11.006. Epub 2020 Nov 13. Cell Metab. 2020. PMID: 33207245 Free PMC article.
Single-Nucleus and In Situ RNA-Sequencing Reveal Cell Topographies in the Human Pancreas.
Tosti L, Hang Y, Debnath O, Tiesmeyer S, Trefzer T, Steiger K, Ten FW, Lukassen S, Ballke S, Kühl AA, Spieckermann S, Bottino R, Ishaque N, Weichert W, Kim SK, Eils R, Conrad C. Tosti L, et al. Among authors: bottino r. Gastroenterology. 2021 Mar;160(4):1330-1344.e11. doi: 10.1053/j.gastro.2020.11.010. Epub 2020 Nov 16. Gastroenterology. 2021. PMID: 33212097 Free article.
227 results