Sebti SM - Search Results

1

Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours.

Zhang X, Blaskovich MA, Forinash KD, Sebti SM. Zhang X, et al. Among authors: sebti sm. Br J Cancer. 2014 Aug 26;111(5):894-902. doi: 10.1038/bjc.2014.349. Epub 2014 Jul 1. Br J Cancer. 2014. PMID: 24983364 Free PMC article.

2

Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.

Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM. Sun J, et al. Among authors: sebti sm. Cancer Res. 2004 May 15;64(10):3586-92. doi: 10.1158/0008-5472.CAN-03-2673. Cancer Res. 2004. PMID: 15150116

3

Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.

Balasis ME, Forinash KD, Chen YA, Fulp WJ, Coppola D, Hamilton AD, Cheng JQ, Sebti SM. Balasis ME, et al. Among authors: sebti sm. Clin Cancer Res. 2011 May 1;17(9):2852-62. doi: 10.1158/1078-0432.CCR-10-2544. Clin Cancer Res. 2011. PMID: 21536547 Free PMC article.

4

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

Patel RA, Forinash KD, Pireddu R, Sun Y, Sun N, Martin MP, Schönbrunn E, Lawrence NJ, Sebti SM. Patel RA, et al. Among authors: sebti sm. Cancer Res. 2012 Oct 1;72(19):5025-34. doi: 10.1158/0008-5472.CAN-12-0954. Epub 2012 Jul 30. Cancer Res. 2012. PMID: 22846914 Free PMC article.

5

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Blaskovich MA, et al. Among authors: sebti sm. Cancer Res. 2003 Mar 15;63(6):1270-9. Cancer Res. 2003. PMID: 12649187

6

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM. Sun J, et al. Among authors: sebti sm. Oncogene. 2005 May 5;24(20):3236-45. doi: 10.1038/sj.onc.1208470. Oncogene. 2005. PMID: 15735720

7

Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors.

Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD, Sebti SM. Sun J, et al. Among authors: sebti sm. Oncogene. 2005 Jul 7;24(29):4701-9. doi: 10.1038/sj.onc.1208391. Oncogene. 2005. PMID: 15897913

8

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Siddiquee K, et al. Among authors: sebti sm. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. doi: 10.1073/pnas.0609757104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463090 Free PMC article.

9

Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM. Kazi A, et al. Among authors: sebti sm. Mol Cell Biol. 2009 Apr;29(8):2254-63. doi: 10.1128/MCB.01029-08. Epub 2009 Feb 9. Mol Cell Biol. 2009. PMID: 19204084 Free PMC article.

10

A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation.

Zhang X, Sun Y, Pireddu R, Yang H, Urlam MK, Lawrence HR, Guida WC, Lawrence NJ, Sebti SM. Zhang X, et al. Among authors: sebti sm. Cancer Res. 2013 Mar 15;73(6):1922-33. doi: 10.1158/0008-5472.CAN-12-3175. Epub 2013 Jan 15. Cancer Res. 2013. PMID: 23322008 Free PMC article.

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