Hunt P - Search Results

1

The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists.

Porter DW, Bradley M, Brown Z, Charlton SJ, Cox B, Hunt P, Janus D, Lewis S, Oakley P, O'Connor D, Reilly J, Smith N, Press NJ. Porter DW, et al. Among authors: hunt p. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3285-90. doi: 10.1016/j.bmcl.2014.06.011. Epub 2014 Jun 14. Bioorg Med Chem Lett. 2014. PMID: 24974342

2

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists.

Porter DW, Bradley M, Brown Z, Canova R, Charlton S, Cox B, Hunt P, Kolarik D, Lewis S, O'Connor D, Reilly J, Spanka C, Tedaldi L, Watson SJ, Wermuth R, Press NJ. Porter DW, et al. Among authors: hunt p. Bioorg Med Chem Lett. 2014 Jan 1;24(1):72-6. doi: 10.1016/j.bmcl.2013.11.074. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24332493

3

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: quaternary amines.

Hunt T, Atherton-Watson HC, Axford J, Collingwood SP, Coote KJ, Cox B, Czarnecki S, Danahay H, Devereux N, Howsham C, Hunt P, Paddock V, Paisley D, Young A. Hunt T, et al. Among authors: hunt p. Bioorg Med Chem Lett. 2012 Jan 15;22(2):929-32. doi: 10.1016/j.bmcl.2011.12.016. Epub 2011 Dec 8. Bioorg Med Chem Lett. 2012. PMID: 22197144

4

A common intracellular allosteric binding site for antagonists of the CXCR2 receptor.

Salchow K, Bond ME, Evans SC, Press NJ, Charlton SJ, Hunt PA, Bradley ME. Salchow K, et al. Among authors: hunt pa. Br J Pharmacol. 2010 Apr;159(7):1429-39. doi: 10.1111/j.1476-5381.2009.00623.x. Epub 2010 Mar 3. Br J Pharmacol. 2010. PMID: 20233217 Free PMC article.

5

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines.

Hunt T, Atherton-Watson HC, Collingwood SP, Coote KJ, Czarnecki S, Danahay H, Howsham C, Hunt P, Paisley D, Young A. Hunt T, et al. Among authors: hunt p. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2877-9. doi: 10.1016/j.bmcl.2012.02.067. Epub 2012 Mar 3. Bioorg Med Chem Lett. 2012. PMID: 22425452

6

Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases.

Petrassi M, Barber R, Be C, Beach S, Cox B, D'Souza AM, Duggan N, Hussey M, Fox R, Hunt P, Jarai G, Kosaka T, Oakley P, Patel V, Press N, Rowlands D, Scheufler C, Schmidt O, Srinivas H, Turner M, Turner R, Westwick J, Wolfreys A, Pathan N, Watson S, Thomas M. Petrassi M, et al. Among authors: hunt p. Front Pharmacol. 2017 May 5;8:240. doi: 10.3389/fphar.2017.00240. eCollection 2017. Front Pharmacol. 2017. PMID: 28529483 Free PMC article.

7

FOCUS--Development of a Global Communication and Modeling Platform for Applied and Computational Medicinal Chemists.

Stiefl N, Gedeck P, Chin D, Hunt P, Lindvall M, Spiegel K, Springer C, Biller S, Buenemann C, Kanazawa T, Kato M, Lewis R, Martin E, Polyakov V, Tommasi R, van Drie J, Vash B, Whitehead L, Xu Y, Abagyan R, Raush E, Totrov M. Stiefl N, et al. Among authors: hunt p. J Chem Inf Model. 2015 Apr 27;55(4):896-908. doi: 10.1021/ci500598e. Epub 2015 Apr 13. J Chem Inf Model. 2015. PMID: 25816021

8

Gazing into the crystal ball; the future of computer-aided drug design.

Martin E, Ertl P, Hunt P, Duca J, Lewis R. Martin E, et al. Among authors: hunt p. J Comput Aided Mol Des. 2012 Jan;26(1):77-9. doi: 10.1007/s10822-011-9487-0. Epub 2011 Nov 17. J Comput Aided Mol Des. 2012. PMID: 22089332 No abstract available.

9

The Australia story: Current status and future challenges for the clinical applications of psychedelics.

Nutt DJ, Hunt P, Schlag AK, Fitzgerald P. Nutt DJ, et al. Among authors: hunt p. Br J Pharmacol. 2024 Dec 19. doi: 10.1111/bph.17398. Online ahead of print. Br J Pharmacol. 2024. PMID: 39701143 Review.

10

Cumulative HIV viral load and lower CD4 cell count are associated with incident venous thromboembolism in people with HIV.

Ruderman SA, Nance RM, Crane HM, Cachay E, Kitahata MM, Napravnik S, Whitney BM, Heckbert SR, Attia EF, Longenecker CT, Hoffmann AP, Budoff MJ, Ma J, Christopoulos K, Hunt PW, Moore RD, Keruly JC, Burkholder G, Bamford L, Willig AL, Chander G, Saag MS, Drumright LN, Feinstein MJ, Crothers K, Delaney JA. Ruderman SA, et al. Among authors: hunt pw. AIDS. 2024 Dec 18. doi: 10.1097/QAD.0000000000004095. Online ahead of print. AIDS. 2024. PMID: 39693493

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