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Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.
Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez DG, Nalls MA, Clark LN, Honig LS, Marder K, Van Der Flier WM, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Compta Y, Revesz T, Lees A, Cairns N, Halliday GM, Mann D, Pickering-Brown S, Dickson DW, Singleton A, Hardy J. Bras J, et al. Hum Mol Genet. 2014 Dec 1;23(23):6139-46. doi: 10.1093/hmg/ddu334. Epub 2014 Jun 27. Hum Mol Genet. 2014. PMID: 24973356 Free PMC article.
ApoE2 allele, Down's syndrome, and dementia.
Royston MC, Mann D, Pickering-Brown S, Owen F, Perry R, Ragbavan R, Khin-Nu C, Tyner S, Day K, Crook R, Hardy J, Roberts GW. Royston MC, et al. Ann N Y Acad Sci. 1996 Jan 17;777:255-9. doi: 10.1111/j.1749-6632.1996.tb34428.x. Ann N Y Acad Sci. 1996. PMID: 8624094
Effect of apolipoprotein E status on clinical features of dementia.
Burlinson S, Burns A, Mann D, Pickering-Brown S, Owen F. Burlinson S, et al. Int J Geriatr Psychiatry. 1998 Mar;13(3):177-85. doi: 10.1002/(sici)1099-1166(199803)13:3<177::aid-gps758>3.0.co;2-m. Int J Geriatr Psychiatry. 1998. PMID: 9565840
Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations.
Houlden H, Rizzu P, Stevens M, de Knijff P, van Duijn CM, van Swieten JC, Heutink P, Perez-Tur J, Thomas V, Baker M, Morris H, Rossor M, Jannsen JC, Petersen RC, Dodd P, Dark F, Boeve B, Dickson D, Davies P, Pickering-Brown S, Mann D, Adamson J, Lynch T, Payami H, Hardy J, et al. Houlden H, et al. Neurosci Lett. 1999 Feb 5;260(3):193-5. doi: 10.1016/s0304-3940(98)00931-8. Neurosci Lett. 1999. PMID: 10076900
198 results